ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A single-cell transcriptomic atlas elucidates the hair cycle and apoptosis mechanisms in goat hair follicles.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Ubiquitin-mediated selective autophagy is essential for innate immune responses against pathogens. However, the role of apoptosis inhibitor 5 (API5), in governing both ubiquitin-mediated autophagy and antiviral immunity, are poorly defined. Here, it is found that the serine/arginine-rich protein kinase 1 (SRPK1)-dependent phosphorylation of API5 at S464 site is essential for priming antiviral immune responses during diverse RNA virus infection. Mechanistically, phosphorylated API5 forms complexes with autophagic receptor p62 and eliminates itself from ubiquitination at K141, thereby reducing p62 aggregations and inhibiting the autophagic degradation of cytosolic RNA sensors RIG-I and MDA5 to mobilize RLR-mediated antiviral responses. Taken together, it is unveiled that API5 phosphorylation by SRPK1 is required for the inhibition of ubiquitin-mediated autophagic degradation of RNA sensors, revealing a coordinating nature of virus-host interactions that sustains host antiviral defenses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.