Evidence map›Paper›PMID 40641806›Full record

ArticleToxicology research2025

Integrative network toxicology, molecular dynamics and transcriptional analysis elucidate DEHP-induced cardiovascular dysfunction.

Yi Guo, Panpan Song, Yanan Liu, Youshan Zhou, Di Cheng, Min Zhu, Wenhao Xu, Pei Qiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi GuoCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.
Panpan SongCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.
Yanan LiuCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.
Youshan ZhouCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.
Di ChengCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.
Min ZhuCollege of Pharmaceutical Sciences, Zhejiang University, 1st Zheda Rd., Hangzhou 310058, China.
Wenhao XuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou, Zhejiang 310014, China.
Pei QiaoCollege of Bioengineering and Biotechnology, Zhejiang University of Technology, 18th Chaowang Rd., Hangzhou 310014, China.ORCID https://orcid.org/0000-0002-4210-4727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diethylhexyl phthalate (DEHP), a ubiquitous environmental pollutant, has been linked to cardiovascular diseases (CVDs), though the molecular mechanisms driving this association remain poorly understood. This study employed an integrated approach combining network toxicology, molecular docking, and molecular dynamics simulations to identify critical gene targets and elucidate their roles in DEHP-induced CVD pathogenesis. Potential clinical targets were screened using public databases (STITCH, ChEMBL, GeneCards, and OMIM), revealing ten core candidates:

Indexed as

cardiovascular diseaseDEHPmolecular dynamicsnetwork toxicologytranscriptional analysis

Identifiers

PMID40641806
PMCPMC12239614

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.