ArticleFrontiers in pharmacology2025
Effects of
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Microbiota to Metabolomics: HowNutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As we get older, we experience a variety of symptoms such as memory and cognitive decline in learning. In the process of aging, neuroinflammatory response is one of the main reasons for the occurrence of cognitive dysfunction. Methods: DOFF samples were extracted by water extraction assisted ultrasonic ethanol method. The DOFF composition was determined by LC-MS/MS method. An aging mouse model was established using D-galactose (D-gal) induced mice. 16S rDNA sequencing was used to analyze intestinal flora, hematoxylin/eosin staining (H&E) and immunohistochemical staining were used to analyze colonic and hippocampal tissue damage and related proteins, and ElISA was used to determine related inflammatory factors. The Y-maze experiment was used to test the cognitive ability of mice, the expression of related synaptic protein was detected by WB, and Iba-1 was labeled by immunofluorescence to study the effects of DOFF on inflammatory response and cognitive function by regulating intestinal microbiota. Results: The results showed that DOFF intervention could regulate the relative abundance of intestinal flora in D-gal mice, including the relative abundance of Discussion: DOFF can improve cognitive dysfunction by regulating intestinal microbiota composition, enhancing intestinal barrier integrity in D-GAL-induced aging mice, improving neuroinflammation, and alleviating hippocampal neuron damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.