ArticleFrontiers in pharmacology2025
Pedunculoside targets P2X7R to protect against myocarditis by regulating the NLRP3/PIP2/MAPK signaling pathway.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric analysis of traditional Chinese medicine for viral infections through immune modulation (2015-2025).Frontiers in immunology · 2025Pooled it
- Box-Behnken Design Optimization of High-Pressure Processed Bitter Melon (International journal of molecular sciences · 2026Article
- Research Progress on the Pharmacological Effects and Network Regulatory Mechanisms of Pedunculoside.International journal of molecular sciences · 2026Review
- ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases.Journal of inflammation research · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Myocarditis is an inflammation of the myocardium caused by a variety of reasons, with myocardial cell necrosis and interstitial inflammatory cell infiltration as the main manifestations. Pedunculoside (PE) plays a protective role in inflammatory diseases; however, it's effect and mechanism on myocarditis remains unexplored. Methods: In this study, we evaluated the cardioprotective effects of PE Results: We found that PE demonstrated inhibition of H9c2 cell death and decreased ROS, Ca Conclusion: Taken together, PE exhibited significant anti-myocarditis activity by interacting with P2X7R and inhibiting the NLRP3, PIP2, and MAPK pathways, highlighting its potential as a therapeutic agent for clinical myocarditis treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.