Evidence map›Paper›PMID 40642164›Full record

ReviewFrontiers in nutrition2025

Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes.

Frédéric Destaillats, Manuel Oliveira, Walter Rakitsky, Xiaoying Zhou, Leon Parker

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Frédéric DestaillatsCheckerspot, Inc., Alameda, CA, United States.
Manuel OliveiraCheckerspot, Inc., Alameda, CA, United States.
Walter RakitskyCheckerspot, Inc., Alameda, CA, United States.
Xiaoying ZhouCheckerspot, Inc., Alameda, CA, United States.
Leon ParkerCheckerspot, Inc., Alameda, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nervonic acid (24:1 n-9, NA) is a monounsaturated very long-chain fatty acid (VLCFA) that plays a fundamental role in brain development, particularly in the biosynthesis of sphingolipids and myelin sheaths. NA is present in minute amounts in human milk and despite its importance in neuronal function and cognitive development, there is currently no ingredient available for the fortification of infant nutrition products. However, recent advances in biotechnology have made it feasible to produce high NA containing oil through fermentation, presenting a significant opportunity to address this nutritional gap. This review explores the potential of NA fortification in infant nutrition products and its impact on neurodevelopment, with a specific focus on two populations: premature infants, who are at higher risk of neurodevelopmental impairments due to incomplete

Indexed as

brain developmentfermentationinfant nutritionmilk-fat globule membranesmyelinationnervonic acidpremature infantssphingolipids

Identifiers

PMID40642164
PMCPMC12240759

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.