Evidence map›Paper›PMID 40642332›Full record

ArticleNational science review2025

Musculoskeletal organoids-on-chip uncover muscle-bone communication under intermittent hypoxia.

Xianqin Tong, Minchao Liu, Jiao Li, Weihua Zhang, Rong Hu, Gang Yang, Jiajia Deng, Yuanyuan Li, Xiaomin Li, Yuehua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xianqin TongDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Minchao LiuDepartment of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai 200000, China.
Jiao LiDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Weihua ZhangDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Rong HuShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai 201100, China.
Gang YangDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Jiajia DengDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Yuanyuan LiDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.
Xiaomin LiShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai 201100, China.ORCID https://orcid.org/0000-0001-6056-6928
Yuehua LiuDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 201100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle and bone have intimate biochemical associations spatiotemporally. Yet, the muscle-bone dynamic alterations under intermittent hypoxia (IH) remain unclear, primarily due to the lack of suitable microphysiological models. Herein, we developed a novel musculoskeletal organoids-on-chip (MSK OoC), advancing an integrated study of muscle-bone biochemical communication and personalized interventional strategies. Within this MSK OoC, muscle organoids (MOs) replicate

Indexed as

intermittent hypoxiaJanus mesoporous nanoparticlesmitochondria-targeted therapymuscle–bone communicationorganoidorganoids-on-chip

Identifiers

PMID40642332
PMCPMC12243851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.