ArticleCureus2025
Usefulness of Two-Dimensional Speckle-Tracking Echocardiography in Detecting Subclinical Left Ventricular Systolic Dysfunction in Diabetes Mellitus.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Three-dimensional Speckle Tracking Imaging to Assess Subclinical Myocardial Mechanical Alterations in Patients With Type 2 Diabetes Mellitus Combined With Subclinical Hypothyroidism.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- How Does Right Atrial Function Differ? A Speckle-Tracking Echocardiographic Comparison of Fetuses With Left Ventricular Outflow Tract Obstruction Versus Those With Significant Tricuspid Regurgitation.Echocardiography (Mount Kisco, N.Y.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate left ventricular (LV) systolic function in asymptomatic patients with diabetes compared to a normal population using global longitudinal strain (GLS) measured by two-dimensional speckle-tracking echocardiography (2DSTE). Impaired LV systolic function was defined as GLS <-18%. Data were analyzed from two groups: a normal cohort (n=57) and a diabetic cohort (n=50). In the normal group, the mean GLS was -20.1%, with 16% of individuals exhibiting impaired LV systolic function. In contrast, the diabetic group demonstrated a significantly lower mean GLS of -17.3%, with 37% showing impaired function, suggesting subclinical myocardial dysfunction in asymptomatic patients with diabetes. Correlation analysis within the diabetic group revealed a moderate negative correlation between GLS and duration of diabetes (r=-0.42, p<0.05), glycated hemoglobin levels (r=-0.35, p<0.05), and low-density lipoprotein cholesterol levels (r=-0.28, p<0.05), indicating that prolonged disease duration and poorer glycemic control are associated with reduced LV systolic function. Further analysis of the normal group revealed no significant gender differences in GLS (p=0.12 ), but age stratification showed a trend toward declining GLS with advancing age (p=0.04 ). These findings underscore the utility of GLS as an early marker of LV dysfunction in asymptomatic patients with diabetes and highlight the influence of age on cardiac function in healthy individuals. Future studies should focus on larger cohorts to validate these results and explore therapeutic interventions to mitigate subclinical cardiac dysfunction in diabetic populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.