ArticleImmunity, inflammation and disease2025
Leucine-Rich Repeat Containing 15 Promotes the Inflammatory Response in Rheumatoid Arthritis by Regulating NF-κB Pathway.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Molecular Structure, Expression, and Emerging Role of the 15-Leucine-Rich Repeat Containing Membrane Protein (LRRC15) in Skeletal Biology and Diseases.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeTo explore the influence and molecular mechanism of leucine-rich repeat containing 15 (LRRC15) in rheumatoid arthritis (RA) model induced by collagen-induced arthritis (CIA) in rats and interleukin-1 beta (IL-1β) treated fibroblast-like synoviocytes (FLSs).
methodsLRRC15 expression was analyzed using reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blot analysis, and immunohistochemistry. Hematoxylin-eosin (H&E) and safranin-O-green staining were performed to assess the pathological changes in the joint tissues of rats. The messenger ribonucleic acid (mRNA) and protein expression of interferon gamma (IFN-γ), interleukin (IL)-6, IL-1β, and IL-10 was detected by RT-qPCR, enzyme-linked immunosorbent assay (ELISA), and western blot. Cell proliferation and migration was surveyed using cell counting kit-8 (CCK-8), 5-Ethynyl-2'-deoxyuridine (EdU), and Transwell assays. Western blot was applied to detect the protein changes of nuclear factor kappaB (NF-κB) subunit p65, phosphorylated (p)-p65, inhibitor of kappa Bα (IκBα), phosphorylated inhibitor kappa Bα (p-IκBα), and nuclear factor erythroid 2-related factor 2 (Nrf2).
resultsIn CIA rats and IL-1β-treated FLSs, LRRC15 expression was upregulated. In vivo, Lrrc15 silencing prevented joint damage, inhibited the expression of IFN-γ, IL-6, IL-1β, and p65, and increased the expression of IL-10 and IκBα. In vitro, Lrrc15 silencing inhibited the proliferation, migration, and the expression of IFN-γ, IL-6, IL-1β, p-p65, and p-IκBα, and increased the expression of IL-10, IκBα, and Nrf2 in FLSs.
conclusionLrrc15 silencing relieved joint damage and inflammatory response in RA, and this may be associated with the inhibition of the NF-κB pathway.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.