Evidence map›Paper›PMID 40642960›Full record

ReviewThe Journal of experimental biology2025

Gut microbial contributions to thermogenesis.

Alexis Kazen, Justin L Grobe, John R Kirby

Abstract readReview
In one paragraph

Review in The Journal of experimental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexis KazenDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-5409-3877
Justin L GrobeDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-9737-0873
John R KirbyDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-2612-0479

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Lysine Acetylation in N. gonorrhoeae Quorum Sensing and Biofilm FormationR01AI108255 · NIAID · UNIVERSITY OF IOWA · PI KIRBY, JOHN R, SCHILLING, BIRGIT · 2014 to 2018
$4.1M
Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9M
The intersection of GLP-1, gut microbiota, and brain connectivity in prodromal Alzheimer’s diseaseR21AG075501 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI KIRBY, JOHN R, UMFLEET, LAURA GLASS · 2022 to 2022
$396k
Investigating how xenobiotics interact with phages to shift energy balanceF31DK137415 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KAZEN, ALEXIS B · 2023 to 2024
$88k
Advancing a Healthier Wisconsin Endowment AG075501Advancing a Healthier Wisconsin Endowment AI108255Butenhoff FamilyMedical College of Wisconsin UL1TR001436NCATS NIH HHS UL1 TR001436NHLBI NIH HHS R01 HL134850NIAID NIH HHS R01 AI108255NIA NIH HHS R21 AG075501NIDDK NIH HHS F31 DK137415NIDDK NIH HHS R01 DK133121NIH HHS 5F31DK137415NIH HHS DK133121NIH HHS HL134850Susanna and Justin Mortara Innovation Fund
6 · The paper itself

Abstract

The role of the gut microbiota in influencing physiological processes has become increasingly evident over the past several decades. One such process, thermogenesis, has become a topic of interest in recent years owing to the threat of climate change as well as the ongoing obesity epidemic. Here, we offer an overview of current knowledge regarding the contributions of the gut microbiota to thermogenesis in ecological and biomedical contexts. We first describe how the metabolic and behavioral changes associated with the gut microbiota can lead to changes in energy balance, allowing animals to adapt to environmental stressors. We then discuss how changes in the gut microbial community composition, such as through antibiotic use, can lead to dysfunctional thermoregulation and, ultimately, disease states. Finally, we consider how microbes can be exploited to improve energy balance and propose some future directions worthy of additional study.

Indexed as

Gastrointestinal MicrobiomeThermogenesisAnimalsAnti-Bacterial AgentsDietHost Microbial InteractionsHumansAnti-Bacterial AgentsEnergy balanceGut microbiomeMetabolismMicrobiotaThermoregulation

Identifiers

PMID40642960
PMCPMC12276805

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.