Evidence map›Paper›PMID 40643025›Full record

ArticleArchiv der Pharmazie2025

Nature-Inspired Compounds Targeting Escherichia coli WrbA as Biofilm-Modulating Agents: Computational Design, Synthesis, and Biological Evaluation.

Matteo Mori, Enrico Mario Alessandro Fassi, Federica Villa, Erica Ginevra Milano, Fabio Forlani, Francesca Cappitelli, Alessandro Ratti, Fiorella Meneghetti, Gabriella Roda, Giovanni Grazioso and 1 more

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matteo MoriDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.
Enrico Mario Alessandro FassiDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.ORCID https://orcid.org/0000-0001-6282-4273
Federica VillaDepartment of Food, Environmental and Nutritional Sciences, University of Milan, Milano, Italy.
Erica Ginevra MilanoDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.
Fabio ForlaniDepartment of Food, Environmental and Nutritional Sciences, University of Milan, Milano, Italy.
Francesca CappitelliDepartment of Food, Environmental and Nutritional Sciences, University of Milan, Milano, Italy.ORCID https://orcid.org/0000-0003-1237-1813
Alessandro RattiDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.
Fiorella MeneghettiDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.ORCID https://orcid.org/0000-0002-6511-7360
Gabriella RodaDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.
Giovanni GraziosoDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.
Stefania VillaDepartment of Pharmaceutical Sciences, University of Milan, Milano, Italy.ORCID https://orcid.org/0000-0002-0636-7589

Funding

This study was supported by funds from the University of Milan-Piano di sostegno alla Ricerca 2023-LINEA 2. A.R. was supported by a young scientist fellowship from the UNIMI GSA-IDEA project.
6 · The paper itself

Abstract

Biofilms pose significant challenges in multiple settings due to their resistance to conventional treatments. In this study, we designed and synthesized a novel class of nature-inspired 5,7-dihydroxy-2,2-dimethylchroman-4-one derivatives as binders of WrbA, a potential target for biofilm modulation. Using a structure-based computational approach, a small library of analogs with varied amide moieties was developed and synthesized. The evaluation of their binding affinity to WrbA demonstrated good-to-excellent K

Indexed as

Anti-Bacterial AgentsBiofilmsChromansDrug DesignEscherichia coliEscherichia coli ProteinsDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular StructureReactive Oxygen SpeciesStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsChromansEscherichia coli ProteinsReactive Oxygen Speciesantibiofilm assaychroman‐4‐one derivativesmicroscale thermophoresisMM‐GBSAreactive oxygen species

Identifiers

PMID40643025
PMCPMC12247152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.