Evidence map›Paper›PMID 40643460›Full record

ReviewAmerican journal of physiology. Cell physiology2025

Sarcoplasmic reticulum-mitochondria microdomains: hugging and kissing in the heart.

Bong Sook Jhun, Jin O-Uchi, Brian Rhee, Ameneh Ahrari, Nathan DeMichaelis, Kye-Im Jeon, David M Booth, Shey-Shing Sheu

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bong Sook JhunDepartment of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, Heart Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.ORCID 0000-0001-9916-9962
Jin O-UchiDepartment of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, Heart Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.ORCID 0000-0001-7566-5400
Brian RheeCardiovascular Division, Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, United States.
Ameneh AhrariDepartment of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, Heart Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
Nathan DeMichaelisCardiovascular Division, Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0009-0002-1914-2423
Kye-Im JeonDepartment of Molecular Pharmacology and Physiology, Hypertension and Kidney Research Center, Heart Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, United States.
David M BoothDepartment of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
Shey-Shing SheuDepartment of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.ORCID 0000-0003-3838-3601

Funding

Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0M
Crosstalk Ca2+ Signaling between Ryanodine Receptors Type 1 and 2 in the Pathogenesis of Cardiac Hypertrophy and Heart FailureR01HL164941 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Shey-Shing Sheu, YONG-XIAO WANG · 2023 to 2026
$2.3M
Regulation of mitochondrial calcium uniporter in the heartR01HL136757 · NHLBI · UNIVERSITY OF MINNESOTA · PI O-UCHI, JIN · 2017 to 2021
$1.9M
Role of ER-mitochondria contact sites in Right Ventricular FibrosisR01HL171710 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Bong Sook Jhun, Jin O-Uchi · 2024 to 2026
$1.7M
Mitochondrial Fission, Calcium, ROS in Right Ventricular FibrosisR01HL160699 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Bong Sook Jhun · 2023 to 2026
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL122124HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136757HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL160699HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL164941HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171710NHLBI NIH HHS R01 HL122124NHLBI NIH HHS R01 HL136757NHLBI NIH HHS R01 HL160699NHLBI NIH HHS R01 HL164941NHLBI NIH HHS R01 HL171710
6 · The paper itself

Abstract

Endoplasmic reticulum (ER)-mitochondrial (ER-Mito) interface, termed mitochondrial-ER contacts (MERCs), plays significant roles in the maintenance of bioenergetics and basal cell functions via the exchange of lipids, Ca

Indexed as

HeartMembrane MicrodomainsMitochondriaMyocytes, CardiacSarcoplasmic ReticulumAnimalsBiological TransportCalcium SignalingEnergy MetabolismHumansMembrane ProteinsMyocardiumMembrane Proteinscalciumcardiac myocyteIP3 receptormitochondria-associated membraneryanodine receptor

Identifiers

PMID40643460
PMCPMC12403979

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.