Evidence map›Paper›PMID 40643479›Full record

ArticleCells2025

Identification of Transcriptomic Differences in Induced Pluripotent Stem Cells and Neural Progenitors from Amyotrophic Lateral Sclerosis Patients Carrying Different Mutations: A Pilot Study.

Chiara Sgromo, Martina Tosi, Cristina Olgasi, Fabiola De Marchi, Francesco Favero, Giorgia Venturin, Beatrice Piola, Alessia Cucci, Lucia Corrado, Letizia Mazzini and 2 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara SgromoDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.
Martina TosiDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-0053-0098
Cristina OlgasiDepartment of Translational Medicine, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-5738-213X
Fabiola De MarchiALS Centre, Neurology Unit, Department of Translational Medicine, Maggiore della Carità Hospital, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-0197-1880
Francesco FaveroDepartment of Translational Medicine, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-3482-8335
Giorgia VenturinDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.
Beatrice PiolaDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.
Alessia CucciDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-5003-831X
Lucia CorradoDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.
Letizia MazziniALS Centre, Neurology Unit, Department of Translational Medicine, Maggiore della Carità Hospital, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-2479-9120
Sandra D'AlfonsoDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.
Antonia FollenziDepartment of Health Sciences, Università degli Studi del Piemonte Orientale, 28100 Novara, Italy.

Funding

The study was supported by the AGING Project for Department of Excellence at the Department of Translational Medicine (DIMET), Università del Piemonte Orientale, Novara, Italy and DIG-ALS, AriSLA Foundation. AF was supported by CSP - Compagnia San Paolo T N. 68155.
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons with a phenotypic and genetic heterogeneity and elusive molecular mechanisms. With the present pilot study, we investigated different genetic mutations (

Indexed as

Amyotrophic Lateral SclerosisInduced Pluripotent Stem CellsMutationNeural Stem CellsTranscriptomeAgedC9orf72 ProteinCell DifferentiationFemaleHumansKruppel-Like Factor 4MaleMiddle AgedPilot ProjectsC9orf72 ProteinKLF4 protein, humanKruppel-Like Factor 4Amyotrophic lateral sclerosisinduced pluripotent stem cellsneural progenitor cellsRNA-seqtranscriptomic analysis

Identifiers

PMID40643479
PMCPMC12249345

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.