Evidence map›Paper›PMID 40643679›Full record

ReviewBiogerontology2025

Advances in brain remodeling, stem cell therapies, and translational barriers in stroke and brain aging.

Bogdan Capitanescu, Dirk M Hermann, Roxana Surugiu, Raphael Guzman, Denissa Greta Olaru, Aurel Popa-Wagner

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bogdan Capitanescu *Doctoral School, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Dirk M Hermann *Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
Roxana SurugiuDoctoral School, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Raphael GuzmanDepartment of Neurosurgery, University Hospital Basel, Basel, Switzerland.
Denissa Greta OlaruDoctoral School, University of Medicine and Pharmacy Craiova, Craiova, Romania. denissagretaolaru@gmail.com.
Aurel Popa-WagnerChair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany. aurel.popa-wagner@geriatrics-healthyageing.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the brain ages, it undergoes a series of molecular and cellular changes that affect its structure and function, contributing to age-related disorders-particularly cerebrovascular diseases and diminished regenerative capacity following ischemic injury. Despite significant research efforts, effective therapies for brain rewiring and functional recovery after cerebral ischemia remain elusive. A deeper understanding of the cellular and molecular mechanisms involved in the post-acute phase of stroke may help identify novel therapeutic strategies for age-associated vascular pathologies. Recent advances have highlighted several promising areas, including epigenetic modifications of the vascular wall, blood-brain barrier remodeling, cell- and subcellular-based therapies, and innovative delivery methods. However, despite encouraging preclinical findings, clinical trials have produced mixed results regarding the safety and efficacy of cell-based interventions. These outcomes suggest that successful stroke therapies in aging populations may require a multistage, integrative approach.

Indexed as

AgingBrainStem Cell TransplantationStrokeAnimalsBlood-Brain BarrierHumansTranslational Research, BiomedicalBrain agingBrain plasticityCell therapiesCerebrovascular diseasesRegenerative capacityRoutes of administration

Identifiers

PMID40643679
PMCPMC12254094

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.