Evidence map›Paper›PMID 40643776›Full record

ReviewPharmaceutical medicine2025

Combating Antimicrobial Resistance: Role of Key Stakeholders with Focus on the Pharmaceutical Sector.

Sangeeta Sharma, Maneesh Paul Satyaseela, Ranga Reddy Burri, Ratnakar Palakodeti, Deepika Pamarthy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pharmaceutical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sangeeta SharmaDepartment of Neuropsychopharmacology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi, 110095, India. sharmasangeeta2003@gmail.com.ORCID 0000-0001-7411-5335
Maneesh Paul SatyaseelaMicrovioma and Lead Co-inventor of Enmetazobactam, (Orchid Pharma), Bengaluru, India.
Ranga Reddy BurriInfection Control Academy of India and Sanmed Healthcare, Hyderabad, India.
Ratnakar PalakodetiHealthcare, Life Sciences and MedTech, Innominds Inc., San Jose, CA, USA.
Deepika PamarthyFederation of Asian Biotech Associations (FABA)-US Chapter, Columbia, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a pressing global health threat fueled by a complex interplay of biological, social, and economic factors. Despite widespread recognition of its impact, the antimicrobial resistance crisis continues to deepen because of inadequate innovation, poor access to effective treatments, and irrational antimicrobial use. Effectively combating antimicrobial resistance requires a multisectoral, multistakeholder, and multidimensional approach, with the pharmaceutical industry playing a pivotal role in new antimicrobial discovery along with diagnostic and other stakeholders. This review critically examines the central role of the pharmaceutical industry in addressing antimicrobial resistance, focusing on drug discovery, manufacturing practices, and stewardship efforts. While the industry has made notable contributions through the development of new antimicrobials and alternative approaches such as drug repurposing, artificial intelligence-driven discovery, and improved diagnostics, major challenges persist-including a declining antibiotic pipeline, limited access in low- and middle-income countries, antimicrobial pollution, irrational fixed-dose combinations, and the prevalence of substandard or falsified drugs. To overcome these barriers, this review explores strategic directions, including public-private partnerships, delinked incentive models, small-molecule innovation, ethical marketing, and equitable access strategies. It also underscores the industry's responsibility in promoting antimicrobial stewardship, participating in global surveillance systems, and educating prescribers and the public on responsible use. Future directions highlight the need for diversified funding, global collaboration, and the adoption of the "triple shield" approach-integrating infection prevention and control, antimicrobial stewardship, and robust surveillance to combat antimicrobial resistance. This review presents an integrated analysis of pharmaceutical accountability, highlighting actionable pathways that align innovation with equitable access, environmental safety, and ethical governance. By bridging gaps between discovery and delivery, the pharmaceutical sector can become a driving force in the global response to antimicrobial resistance.

Indexed as

Anti-Bacterial AgentsDrug IndustryDrug Resistance, BacterialDrug Resistance, MicrobialAntimicrobial StewardshipDrug DiscoveryDrug RepositioningGlobal HealthHumansPublic-Private Sector PartnershipsStakeholder ParticipationAnti-Bacterial Agents

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.