Evidence mapPaperPMID 40643786Full record

ReviewMolecular biology reports2025

Potential role of terpenes in recovery from olfactory dysfunction with olfactory training: a review.

Aytug Altundag, Emirhan Harbi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aytug AltundagDepartment of Otorhinolaryngology, Biruni University School of Medicine, Istanbul, Turkey. aaltundagkbb@gmail.com.
Emirhan HarbiAltundag Life Clinic, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sense of smell is an important part of everyday life, yet many people around the world live with olfactory dysfunction or smell loss. The most common causes of olfactory dysfunction include upper respiratory tract infections, sinus diseases, and traumatic brain injury. Current treatment options are limited, and olfactory training is the most commonly used method clinically. Terpenes are volatile organic compounds found in plants that exhibit anti-inflammatory, neuroprotective, and anti-cancer effects. This review addresses the potential benefits of terpene use in olfactory training and proposes the development of a new terpene-centered training protocol. Terpenes have been shown to provide anti-inflammatory effects by inhibiting the NF-κB signaling pathway and may modulate olfactory receptors. Furthermore, they have the potential to provide neuroprotection, tissue regeneration, and neuroprotection by interacting with the endocannabinoid system and various cellular signaling pathways. This study aims to further understand the effects of terpenes in the treatment of olfactory dysfunctions and to develop new strategies to increase the efficacy of olfactory training.

Indexed as

Olfaction DisordersTerpenesAnimalsAnti-Inflammatory AgentsHumansNeuroprotective AgentsOlfactory TrainingSignal TransductionSmellAnti-Inflammatory AgentsNeuroprotective AgentsTerpenesCancer signaling pathwaysEssential oilsOlfactory dysfunctionOlfactory trainingTerpenes

Identifiers

PMID40643786

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.