Evidence map›Paper›PMID 40643797›Full record

Trial reportJournal of behavioral medicine2025

A phase II pilot randomized controlled trial of an integrated stepped collaborative care intervention for patients awaiting kidney transplantation (CARES-transplant).

Cramer J Kallem, Amit A Tevar, Tyler Bradley, Heather Jackson, Denise Haggerty, Hannah Cheng, Ritambhara Pathak, Yisi Wang, Maureen Carney, Shelby Gardner and 3 more

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Publisher
In one paragraph

Trial report in Journal of behavioral medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02938351 (Collaborative Care Intervention for Kidney Transplant Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02938351 nacompletednot on this map

Collaborative Care Intervention for Kidney Transplant Patients

TypeinterventionalSponsorUniversity of PittsburghRan2016 to 2021Enrolled10ConditionsKidney Transplant, Depression, PainArmsCollaborative care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cramer J KallemRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Amit A TevarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Tyler BradleyDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Heather JacksonDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Denise HaggertyDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Hannah ChengDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Ritambhara PathakDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Yisi WangDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Maureen CarneyDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Shelby GardnerDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Athrva DeshpandeDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Manisha JhambRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jennifer L SteelDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA. steejl@upmc.edu.ORCID http://orcid.org/0000-0002-1959-1854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients awaiting kidney transplant carry a high symptom burden which has been associated with waitlist inactivation, mortality, and poorer post-transplant outcomes. However, few studies have tested the effects of symptom management interventions in this population. This Phase II study aimed to (1) test the feasibility and preliminary efficacy of an integrated stepped collaborative care intervention (CARES-Transplant) on patient-reported outcomes and unplanned healthcare utilization, and (2) explore treatment effects on family caregiver outcomes. The study was a randomized controlled trial designed to test the efficacy of CARES-Transplant versus standard of care (SC). Patients completed a battery of questionnaires at baseline and 3-months including the Center for Epidemiological Studies-Depression (CES-D) scale, Brief Pain Inventory, and Functional Assessment of Chronic Illness Therapy-Fatigue, and Rand Short Form-36. Caregivers were administered the CES-D, Perceived Stress Scale, and Pittsburgh Sleep Quality Index at baseline and 3-months. Patient unplanned health care utilization was assessed over the course of one-year post-randomization. Nineteen patients (mean age = 65 ± 6 years, 74% male, 90% White) and 8 caregivers (mean age = 61.3 ± 8.1 years, 100% female and white) were randomized. Reductions in pain intensity and interference were observed for CARES (- 0.2) while patients in the SC arm had increases in pain intensity and interference (+ 1.3, ES = 0.30). Similar trends were observed for fatigue (CARES = - 0.4 versus SC = - 7.7, ES = 0.41) and depressive symptoms (CARES = - 2.0 versus SC =  + 2.33, ES = 0.56). Lower rates of transplant-related complications (CARES mean = 1 versus SC = 3), fewer emergency room visits (CARES = 1.0 versus SC = 2.67) and 90-day readmissions (CARES = 0% versus SC = 28.6%) were also observed. A moderate to large effect size was observed for changes on caregiver reported depressive symptoms (CARES =  + 0.5 versus SC =  + 3.3, ES = 0.55) and sleep quality (CARES = - 1.5 versus SC =  + 0.07, ES = 0.34). The findings of this pilot study warrant a Phase III trial to test the efficacy of CARES-Transplant.Clinical trials registration number ClinicalTrials.gov NCT02938351.

Indexed as

Kidney TransplantationAgedCaregiversDepressionFatigueFemaleHumansMaleMiddle AgedPatient Acceptance of Health CarePatient Reported Outcome MeasuresPilot ProjectsWaiting ListsCollaborative careDepressionFatigueKidney transplantPainQuality of life

Identifiers

PMID40643797

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.