Evidence map›Paper›PMID 40644296›Full record

ArticleCell reports2025

The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint.

Juliana N Flaherty, Enakshi Sivasudhan, Matthew Tegowski, Zheng Xing, Madeline M McGinnis, Olga V Hunter, Kyah M Featherston, Komal Sethia, Benjamin P Tu, Kate D Meyer and 1 more

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. mCells · 2025
    Review
  7. Article
  8. Understanding the Molecular Basis of Miller-Dieker Syndrome.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juliana N FlahertyDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Enakshi SivasudhanDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Matthew TegowskiDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Zheng XingDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Madeline M McGinnisDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Olga V HunterDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kyah M FeatherstonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Komal SethiaDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Benjamin P TuDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kate D MeyerDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Nicholas K ConradDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: nicholas.conrad@utsouthwestern.edu.

Funding

Center for Multi-Scale Analysis of the Human EpitranscriptomeRM1HG011563 · NHGRI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Kathryn D Meyer · 2021 to 2026
$22.2M
Mechanisms of KSHV posttranscriptional gene regulationR01AI123165 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CONRAD, NICHOLAS K · 2016 to 2025
$4.5M
Metabolic signals regulating cell growth versus survivalR35GM136370 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin P Tu · 2020 to 2026
$2.8M
Mechanisms regulating KSHV transcription elongation and terminationR01AI153175 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI CONRAD, NICHOLAS K · 2021 to 2025
$2.3M
Mechanisms of posttranscriptional regulation of SAM homeostasisR01GM127311 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CONRAD, NICHOLAS K · 2019 to 2022
$1.4M
NHGRI NIH HHS RM1 HG011563NIAID NIH HHS R01 AI123165NIAID NIH HHS R01 AI153175NIGMS NIH HHS R01 GM127311NIGMS NIH HHS R35 GM136370
6 · The paper itself

Abstract

The methyl donor S-adenosylmethionine (SAM) regulates many cellular processes. The N6-methyladenosine (m

Indexed as

MethyltransferasesS-AdenosylmethionineHCT116 CellsHistonesHumansMethionine AdenosyltransferaseMethylationHistonesMAT2A protein, humanMethionine AdenosyltransferaseMethyltransferasesMETTL16 protein, humanS-AdenosylmethionineCP: Molecular biologyintron retentionMAT2AmethylationMETTL16MTAPSAM

Identifiers

PMID40644296
PMCPMC12330366

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.