Evidence map›Paper›PMID 40644535›Full record

ArticleScience advances2025

Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution.

Rizwanul Haque, Hagar Setty, Ramiro Lorenzo, Gil Stelzer, Ron Rotkopf, Yehuda Salzberg, Gal Goldman, Sandeep Kumar, Shiraz Nir Halber, Andrew M Leifer and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026
    Article
  5. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. microPublication biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Rizwanul HaqueDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0002-3968-6359
Hagar SettyDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0002-6857-4583
Ramiro LorenzoLaboratory of Neurophysiology, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0002-1860-9418
Gil StelzerBioinformatics Unit, Life Science Core Facilities, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9368-4912
Ron RotkopfBioinformatics Unit, Life Science Core Facilities, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9503-7348
Yehuda SalzbergDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Gal GoldmanDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0003-1996-3213
Sandeep KumarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-7181-232X
Shiraz Nir HalberDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0009-0006-9539-1359
Andrew M LeiferPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-5362-5093
Elad SchneidmanDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0001-8653-9848
Patrick LaurentLaboratory of Neurophysiology, ULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0001-5360-5597
Meital Oren-SuissaDepartment of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0001-9937-8326

Funding

WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NHGRI NIH HHS U41 HG002223NIH HHS P40 OD010440NIH HHS R24 OD010943
6 · The paper itself

Abstract

Sex-specific behaviors are often attributed to differences in neuronal wiring and molecular composition, yet how genetic sex shapes the molecular architecture of the nervous system at the individual neuron level remains unclear. Here, we use single-cell RNA sequencing to profile the transcriptome of sex-shared neurons in adult

Indexed as

Caenorhabditis elegansNervous SystemNeuronsSex CharacteristicsAnimalsCaenorhabditis elegans ProteinsFemaleGene Expression ProfilingMaleNeuropeptidesSingle-Cell AnalysisTranscriptomeCaenorhabditis elegans ProteinsNeuropeptides

Identifiers

PMID40644535
PMCPMC12248294

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.