Evidence map›Paper›PMID 40644553›Full record

ArticleScience advances2025

G proteins of the G

Dhanush Haspula, Zhenzhong Cui, Srinivas Pittala, Yinghong Cui, Huiyan Lu, Yan Xiong, Jian Jin, Oksana Gavrilova, Eunsang Hwang, Jason Ajwani and 4 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Activation of GScience advances · 2026
    Article
  2. Chemogenetic Activation of GFASEB bioAdvances · 2026
    Article
  3. Article
  4. Serotonin 5-HTACS chemical neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dhanush HaspulaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0003-2096-6163
Zhenzhong CuiMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Srinivas PittalaMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-8873-1320
Yinghong CuiMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-9889-6655
Huiyan LuMouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Yan XiongMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3862-3663
Jian JinMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-2387-3862
Oksana GavrilovaMouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0002-9310-1198
Eunsang HwangCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4298-5368
Jason AjwaniCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bryan PortilloCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kevin W WilliamsCenter for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-8434-8658
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.ORCID 0000-0003-0805-4049
Jürgen WessMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0003-0818-1232

Funding

Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2019 to 2023
$10.0M
Cellular and Synaptic Reorganization after Exercise TrainingR01DK119169 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2018 to 2021
$1.6M
Programmed Changes in Alternative Splicing Within the Erythroid TranscriptomeR21DK075021 · NIDDK · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CONBOY, JOHN G · 2006 to 2007
$462k
Acute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activityR56DK135501 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAMS, KEVIN W · 2024 to 2024
$410k
NIDDK NIH HHS P01 DK119130NIDDK NIH HHS R01 DK119169NIDDK NIH HHS R21 DK075021NIDDK NIH HHS R56 DK135501
6 · The paper itself

Abstract

Proopiomelanocortin (POMC) neurons play a key role in maintaining glucose and energy homeostasis. POMC neurons express many heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors that are linked to different functional classes of G proteins. The potential role of G

Indexed as

NeuronsPro-OpiomelanocortinAnimalsBenzazepinesEnergy MetabolismGlucoseLeptinMaleMiceMice, KnockoutObesitySignal TransductionBenzazepinesGlucoseLeptinlorcaserinPro-Opiomelanocortin

Identifiers

PMID40644553
PMCPMC12248387

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.