ArticleFree radical biology & medicine2025
Breaking the vicious cycle in sickle cell disease: Redox stress impairs red blood cell rheology and promotes lung vasocongestion.
Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A novel transdermal curcumin gel shows potential in improving cardiac bioenergetic functions in Berkeley sickle cell mice.Blood vessels, thrombosis & hemostasis · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Sickle cell disease (SCD) is characterized by impaired red blood cell (RBC) rheology, including increased hemoglobin S (HbS) polymerization, reduced sickle RBC deformability, and elevated blood viscosity, all features that promote lung vasocongestion and contribute to acute and chronic lung disease. Currently, there is an urgent need for new therapies to improve RBC rheology. Here, we investigate whether N-acetyl-lysyltyrosylcysteine amide (KYC), a redox-modulating end-capped tripeptide, improves RBC rheology by reducing oxidative stress. Steady-state and vaso-occlusive crisis (VOC) were modeled in SS mice using normoxic (NOX) and hypoxia/reoxygenation (H/R) protocols. KYC inhibition of HbS oxidation was assessed in vitro. The effects of KYC on plasma advanced oxidation protein products (AOPP), hematocrit (%Hct), blood viscosity, RBC sickling, lung vasocongestion, and RBC reactive oxygen species (ROS) in the mice were determined ex vivo. In vitro, KYC reduced H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.