Evidence map›Paper›PMID 40645964›Full record

ArticleNature communications2025

Differential ER stress responses during lactation and postpartum outcomes in mice depending on their mitochondrial genotype.

Mrittika Chattopadhyay, Edmund Charles Jenkins, William Janssen, Thelma Mashaka, Doris Germain

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mrittika ChattopadhyayIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA.
Edmund Charles JenkinsIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA.
William JanssenIcahn School of Medicine at Mount Sinai, Microscopy and Advanced Bioimaging Core, New York, 10029, NY, USA.
Thelma MashakaIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA.
Doris GermainIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA. doris.germain@mssm.edu.ORCID http://orcid.org/0000-0001-6597-0196

Funding

Exploring ovarian-derived hormone STC1 as the mediator of the protective effect of breast feeding against breast cancer.R21CA270702 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GERMAIN, DORIS A · 2023 to 2024
$423k
NCI NIH HHS R21 CA270702U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R21CA270702
6 · The paper itself

Abstract

Breastfeeding protects against breast cancer in some women but not others, however the mechanism remains elusive. Lactation requires intense secretory activity of the endoplasmic reticulum for the production of milk proteins and endoplasmic reticulum- mitochondria contacts for lipid synthesis. We show that in female mice that share the same nuclear genome (BL/6) but differ in mitochondrial genomes (

Indexed as

Endoplasmic Reticulum StressLactationMitochondriaPostpartum PeriodAnimalsApoptosisBreast NeoplasmsEndoplasmic ReticulumFemaleGenome, MitochondrialGenotypeHumansMiceMice, Inbred C57BLTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID40645964
PMCPMC12254486

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.