Evidence map›Paper›PMID 40646161›Full record

ArticleScientific reports2025

CD20-bearing extracellular vesicles are associated with prognostic biomarkers of patients with AIDS-NHL.

Laura E Martínez, Shelly Lensing, Di Chang, Larry I Magpantay, Yu Guo, Ronald Mitsuyasu, Richard F Ambinder, Joseph A Sparano, Otoniel Martínez-Maza, Marta Epeldegui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura E MartínezUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Shelly LensingSt. Jude Children's Research Hospital, Memphis, TN, USA.
Di ChangUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Larry I MagpantayUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Yu GuoUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Ronald MitsuyasuUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Richard F AmbinderDivision of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, John Hopkins University, Baltimore, MD, USA.
Joseph A SparanoDivision of Hematology Oncology, Mount Sinai, NY, USA.
Otoniel Martínez-MazaUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Marta EpeldeguiUCLA AIDS Institute and David Geffen School of Medicine, University of California, Los Angeles, CA, USA. mepeldegui@mednet.ucla.edu.

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
The Role of Follicular CD8+ T Cells in Pathogenesis of AIDS-NHL.R01CA228157 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA · 2019 to 2023
$1.8M
Mucosal B-cell aging in PLWHR56AG086059 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA, YANG, OTTO O · 2024 to 2024
$393k
PDL1 expression on B cells: a potential marker of pre-tumor cells in AIDS-NHLR21CA220475 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EPELDEGUI, MARTA · 2017 to 2018
$372k
NCI NIH HHS R01 CA228157NCI NIH HHS R01-CA228157NCI NIH HHS R01-CA228157SNCI NIH HHS R21 CA220475NCI NIH HHS U01 CA121947NCI NIH HHS UM1 CA121947NCI NIH HHS UM1-CA121947NIA NIH HHS R56 AG086059
6 · The paper itself

Abstract

CD20 is a tetraspan membrane-bound protein vital for the development, activation, and differentiation of human B-cells. Non-Hodgkin lymphoma (NHL) is the most common hematological cancer in people living with (PLWH), and most B-cell NHLs express CD20. Extracellular vesicles (EVs) are nanosized vesicles released by cells into the extracellular environment. Here, we examined the association between plasma-derived CD20

Indexed as

Antigens, CD20Biomarkers, TumorExtracellular VesiclesLymphoma, AIDS-RelatedLymphoma, Non-HodgkinAdultCell Line, TumorFemaleHumansLymphoma, Large B-Cell, DiffuseMaleMiddle AgedPrognosisRituximabAntigens, CD20Biomarkers, TumorRituximabAIDS-associated non-Hodgkin lymphoma (AIDS-NHL)Anti-CD20CD20EPOCHExtracellular vesiclesRituximab

Identifiers

PMID40646161
PMCPMC12254413

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.