Evidence map›Paper›PMID 40646241›Full record

ArticleScientific reports2025

LEO or LEO baby within enterprise overlapping stents combined with coil embolization treatment for ruptured vertebrobasilar artery dissecting aneurysms.

Zengbao Wu, Minghui Zhou, Ali Abdi Maalim, Yang Han, Xiao Guo, Cao Chen, Ting Lei, Kai Shu, Mingxin Zhu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zengbao Wu *Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Minghui Zhou *Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ali Abdi MaalimDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yang HanDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiao GuoDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cao ChenDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ting LeiDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Kai ShuDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. kshu@tjh.tjmu.edu.cn.
Mingxin ZhuDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. mxzhu@tjh.tjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study sought to evaluate the feasibility and effectiveness of the LEO or LEO baby within enterprise (EP) overlapping stents for treating ruptured vertebrobasilar artery dissecting aneurysms (VBDAs). A retrospective analysis was conducted on 20 patients with a total of 20 ruptured VBDAs, who received reconstructive treatment utilizing the LEO/LEO baby within enterprise overlapping stents combined with coil embolization, between December 2018 and June 2023. Patient characteristics, clinical outcomes, and radiological results were thoroughly reviewed. Functional data were evaluated using the modified Rankin scale (mRS). The outcomes for patients treated with the overlapping stent technique were compared to those of the single-stent treatment group which included 14 cases with LEO/LEO Baby stent and 12 cases with Enterprise stent. Among the 20 ruptured VBDAs identified, 13 were vertebral artery aneurysms (65.00%), and 7 were basilar artery aneurysms (35.00%). All cases were effectively treated during the acute phase of onset. Three patients (15.00%) experienced significant in-hospital adverse events, with one patient (5.00%) succumbing to rebleeding of the arterial aneurysm during the perioperative period. A follow-up period of at least six months was achieved for 19 patients. The rates of mortality or dependency (mRS scores of 3 to 6) were 15.00% at discharge and 10.00% at the final follow-up. Ischemic events occurred in two patients (10.00%); one during the perioperative period and one during follow-up. One patient (5.00%) required ventriculoperitoneal shunt placement. Immediate post-operation angiography revealed Raymond grade I, II, and III occlusions in 55.00%, 30.00%, and 15.00% of cases, respectively. At a mean follow-up of 14.84 ± 7.51 months, 17 patients (89.47%) had mRS scores of 0-2, indicating favorable outcomes, while two patients (10.53%) had scores between 3 and 6. The initial complete or near-complete obliteration rates of aneurysms were higher in the overlapping-stent group compared to the single-stent group (85.00% vs. 65.38%, P = 0.18). Follow-up angiography indicated superior rates of complete or near-complete aneurysm obliteration in the double-stent group (94.74% vs. 73.08%, P = 0.11). The overlapping stents technique, utilizing the LEO/LEO baby within EP stent configuration in conjunction with coiling, demonstrated both efficacy and safety in the treatment of ruptured VBDAs. Follow-up evaluations revealed a high rate of aneurysm occlusion, suggesting that this approach may offer a dependable intervention strategy for managing these complex cases.

Indexed as

Aneurysm, RupturedAortic DissectionEmbolization, TherapeuticIntracranial AneurysmStentsVertebral Artery DissectionAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeDual overlapping stents techniqueEndovascular treatmentEnterprise stentLEO/LEO baby stentRuptured vertebrobasilar artery dissecting aneurysms

Identifiers

PMID40646241
PMCPMC12254310

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.