Evidence map›Paper›PMID 40646282›Full record

ArticlePediatric research2026

Allergy and atopic phenotype are associated with earlier gestation and severity of respiratory symptoms in bronchopulmonary dysplasia.

Brianna C Aoyama, Joseph M Collaco, Amit Agarwal, Gangaram Akangire, Eric D Austin, Manvi Bansal, Anita Bhandari, A Ioana Cristea, Lystra P Hayden, Jonathan C Levin and 16 more

Abstract read
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In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Brianna C AoyamaEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA. baoyama1@jhmi.edu.
Joseph M CollacoEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA.
Amit AgarwalDivision of Pulmonary Medicine, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Gangaram AkangireDivision of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
Eric D AustinPulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Manvi BansalPulmonology and Sleep Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Anita BhandariDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
A Ioana CristeaDivision of Pediatric Pulmonology, Allergy and Sleep Medicine, Riley Children's Hospital and Indiana University, Indianapolis, IN, USA.
Lystra P HaydenDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Jonathan C LevinDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Winston M ManimtimDivision of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
Audrey N MillerDivision of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, OH, USA.
Paul E MoorePulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Antonia P PopovaPediatric Pulmonology, University of Michigan, Ann Arbor, MI, USA.
Lawrence M RheinNeonatal-Perinatal Medicine/Pediatric Pulmonology, University of Massachusetts, Worcester, MA, USA.
Catherine A SheilsDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Steven H AbmanSection of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Christopher D BakerSection of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Sara K DawsonDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
Mehtap Haktanir AbulDepartment of Pediatrics, Brown University School of Medicine, Providence, RI, USA.
Jennifer K HenningfeldDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
Joanne M LagattaDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
Roopa SiddaiahPediatric Pulmonology, Penn State Health, Hershey, PA, USA.
Nicole StephensonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Demet ToprakDivision of Pediatric Pulmonary and Sleep Medicine, University of Washington, Seattle, WA, USA.
Sharon A McGrath-MorrowDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA history of atopy is associated with respiratory morbidities in term-born children; however, little is known about how allergies/atopy affect respiratory outcomes in children with bronchopulmonary dysplasia (BPD). This study aims to describe the prevalence of reported allergies/atopy in young children with BPD and assess whether allergies/atopy are associated with outpatient outcomes.

methodsA retrospective longitudinal cohort study of children between 0 and 36 months of age followed at outpatient BPD clinics was performed using data from questionnaires administered during routine clinical encounters. The presence of allergy/atopy was defined by caregiver questionnaires. Generalized estimating equations were used to adjust associations between allergy/atopy and respiratory outcomes.

resultsRates of reported allergy/atopy in a cohort of infants and children with BPD (21.6%) were similar to previously published rates in healthy children. Children with atopy/allergy were more likely to be born at earlier gestational ages, have pulmonary hypertension, and be non-white and non-Hispanic compared to their non-atopic peers and to experience trouble breathing, nighttime symptoms, activity limitations, and rescue medication use during the first three years of life.

conclusionsIn children with BPD, allergy/atopy was more common among those born at earlier gestational ages and was significantly associated with increased respiratory symptoms during the first 3 years of life. Further studies are needed to assess whether the association between allergy/atopy and increased respiratory morbidity persists throughout childhood and affects later lung function and whether potential interventions, including inhaled steroids, may modify this risk. IMPACT: There is limited data on the prevalence of atopy/allergy in children with bronchopulmonary dysplasia (BPD) and the association between allergy/atopy and respiratory outcomes in this population. Our findings demonstrate that in children with BPD, allergy/atopy was more common among those born at earlier gestational ages and was associated with increased respiratory symptoms and rescue medication use during the first 3 years of life. Further studies are needed to determine whether this association persists throughout childhood and affects later lung function and whether potential interventions may modify this risk.

Indexed as

Bronchopulmonary DysplasiaHypersensitivityChild, PreschoolFemaleGestational AgeHumansInfantInfant, NewbornLongitudinal StudiesMalePhenotypePrevalenceRetrospective StudiesSeverity of Illness IndexSurveys and Questionnaires

Identifiers

PMID40646282

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.