Ameliorative role of Polyscias fruticosa leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by N-methyl-D-aspartate receptor antagonistic and anticholinesterase active compounds.

Dao Thi Anh Phan, Hien Phung Le, Tran Huyen Tran, Ut Van Le, Minh Van Le, Trieu Hai Ly

Abstract read

In one paragraph

Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dao Thi Anh PhanFaculty of Chemical and Food Technology, HCMC University of Technology and Education, Ho Chi Minh City, 700000, Vietnam.ORCID http://orcid.org/0000-0002-8482-6306

Hien Phung LeCollege of Science and Engineering, Flinders University, Sturt Rd, Bedford Park, SA, 5042, Australia.ORCID http://orcid.org/0000-0002-5675-152X

Tran Huyen TranBinh Duong University, Binh Duong, 820000, Vietnam.ORCID http://orcid.org/0009-0001-2379-1365

Ut Van LeBinh Duong University, Binh Duong, 820000, Vietnam.ORCID http://orcid.org/0009-0000-0392-7846

Minh Van LeResearch Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh City, 700000, Vietnam.ORCID http://orcid.org/0000-0003-4541-2319

Trieu Hai LyResearch Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh City, 700000, Vietnam. lhtrieu12csh@gmail.com.ORCID http://orcid.org/0000-0002-3610-7964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyscias fruticosa leaves have been used in traditional medicine to aid in the therapy of brain and nerve-related disorders, including dementia. However, the evidences for the effects and mechanisms of P. fruticosa leaf extract (PFLE) and its constituents in improving dementia remain unclear. This study aims to evaluate the ameliorative effect of PFLE in aluminum chloride-induced neurotoxicity Drosophila melanogaster model. Simultaneously, the dementia-improving mechanisms of PFLE's compounds were explored by computational pharmacological analysis. Results showed that D. melanogaster exposed to 1.0, 2.0, and 4.0 mg/mL PFLE or 0.1 mg/mL donepezil hydrochloride had significant improvements in lifespan, memory, motor behavior, and oxidative stress markers, including decreased malondialdehyde level and increased glutathione level in flies' homogenates. Also, PFLE had acetylcholinesterase inhibitory ability with an IC

Indexed as

Cholinesterase InhibitorsFabaceaePlant ExtractsReceptors, N-Methyl-D-AspartateAcetylcholinesteraseAluminum ChlorideAnimalsDrosophila melanogasterMolecular Docking SimulationOxidative StressPlant LeavesAcetylcholinesteraseAluminum ChlorideCholinesterase InhibitorsPlant ExtractsReceptors, N-Methyl-D-AspartateAluminum chloride (AlCl3)Alzheimer’s diseaseAnti-cholinesteraseNeurotoxicityN-Methyl-d-aspartate (NMDA) receptor antagonistsPolyscias fruticosa leaves

Identifiers

PMID40646316

DOI10.1007/978-3-319-41334-1_8

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.