ArticleAnnals of biomedical engineering2025
Interface Performance Enhancement in 3D-Printed Biphasic Scaffolds with Interlocking Hourglass Geometry.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The application of tissue engineering in cartilage regeneration: technological advances and future challenges.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
2 authors.
Funding
Abstract
The cartilaginous surfaces in ginglymus (hinge) joints such as the knee, elbow, and the ginglymoarthrodial temporomandibular joint (TMJ) primarily function under unidirectional shear and orthogonal compression. Regenerative medicine approaches to treat injured or arthritic joints include biphasic scaffolds, which must withstand the joint's biomechanical demands. In the current study, we leveraged computational modeling to design a 3D-printed biphasic scaffold with enhanced biomechanical performance for ginglymus joints. A sinusoidal hourglass tube geometry was introduced to support shear stresses at the hydrogel-substrate interface and to support orthogonal compression. Biphasic constructs were evaluated with both empirical and in silico interface shear experiments. A thermal extrusion 3D-printed polylactic acid (PLA) hourglass interface was infilled with a hydrogel, comprised of either (1) agarose or (2) pentenoate-modified hyaluronic acid (PHA), polyethylene glycol diacrylate (PEGDA), and devitalized cartilage (DVC). Shear loads were applied either parallel to the tube's long axis (i.e., 1-direction) or orthogonally (i.e., 2-direction). Additionally, the hourglass tube architecture without any hydrogel was evaluated in compression in the 1- and 3-directions. Empirically, ultimate interface shear stresses up to 51 ± 7 kPa were observed for the infilled PHA-PEGDA-DVC hydrogels, with higher values in both loading directions compared to a crosshatch scaffold as a standard-of-comparison control (p < 0.05). The computer model suggested a geometry-dependent shear load transfer. The ultimate compressive stress for the hourglass architecture in the 3-direction reached 6.9 ± 1.8 MPa, which was 39% higher than the crosshatch architecture. The hourglass design enhanced performance under shear in the 1-direction and compression in the 3-direction, which may add value for future designs employed for regenerating tissues in ginglymus joints that primarily function under unidirectional shear and orthogonal compression.
Indexed as
Identifiers
40646321What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.