Evidence map›Paper›PMID 40646329›Full record

ReviewHuman cell2025

Senescence of dental pulp stem cells: phenotypes, underlying mechanisms and regulatory molecules.

Ping Zhang, Yu Cui, Zekun Li, Luyun Liu, Xinjuan Liu, Xiaoling Ding, Gang Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ping Zhang *School of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China.
Yu Cui *School of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China.
Zekun LiSchool of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China.
Luyun LiuSchool of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China.
Xinjuan LiuSchool of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China.
Xiaoling DingClinical Competency Training Center, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China. wfyxydxl@163.com.
Gang DingSchool of Stomatology, Shandong Second Medical University, Baotong West Street No. 7166, Weifang, 261053, Shandong, China. dinggang@sdsmu.edu.cn.ORCID http://orcid.org/0000-0003-4597-1639

Funding

National Natural Science Foundation of China 81570945Natural Science Foundation of Shandong Province ZR2023QH506Natural Science Foundation of Shandong Province ZR2024MH147Weifang Kite Capital Scholars Program ydxz2023002
6 · The paper itself

Abstract

Dental pulp stem cells (DPSCs) are a population of adult stem cells with self-renewal capacity and multilineage differentiation potential, widely utilized in tissue engineering and regenerative medicine. However, with increasing donor age or prolonged in vitro expansion, DPSCs gradually exhibit senescence-associated phenotypes, including reduced proliferative capacity and impaired differentiation potential. This review comprehensively summarizes current advances in the study of DPSCs senescence. First, it explores how the aging dental pulp microenvironment influences the biological characteristics of DPSCs. It then focuses on the interplay between DPSCs senescence and mitochondrial dysfunction, epigenetic alterations, as well as key signaling pathways such as p53/p21/p16. On this basis, recent molecular strategies for delaying DPSCs senescence are discussed, such as melatonin can alleviate DPSCs senescence by inhibiting the expression of matrix metalloproteinase, and metformin could interfere DPSCs senescence by AMPK/mTOR signaling pathway, etc. Lastly, a comparative analysis of senescence characteristics among DPSCs, bone marrow and adipose derived mesenchymal stem cells, is conducted to contextualize the unique and shared features of these cell types. Collectively, this review could provide a theoretical foundation and practical insights for advancing anti-senescence strategies in DPSC-based regenerative applications.

Indexed as

Cellular SenescenceDental PulpStem CellsCell DifferentiationCell ProliferationEpigenesis, GeneticHumansMelatoninMesenchymal Stem CellsMitochondriaPhenotypeRegenerative MedicineSignal TransductionMelatoninDental pulp stem cellsEpigenetic regulationInterventionMitochondrial metabolic disorderSenescence mechanism

Identifiers

PMID40646329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.