Evidence map›Paper›PMID 40646458›Full record

Trial reportBMC geriatrics2025

Impact of collaborative pharmaceutical care on older inpatients' medication safety: multicentre stepped-wedge cluster randomised trial (MEDREV Study).

Géraldine Leguelinel-Blache, Sophie Bouvet, Pierrick Bedouch, Bérengère Bachelet, Catherine Chenailler, Thomas Dantin, Laure Geneletti, Alexia Janes, Florence Scher, Bogdan Cireașă and 5 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02598115 (Impact of the Implementation of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02598115 nacompletednot on this map

Impact of the Implementation of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older

TypeinterventionalSponsorCentre Hospitalier Universitaire de NīmesRan2016 to 2016Enrolled622ConditionsAged, Patient Admission, HospitalizationArmsCollaborative Pharmaceutical Care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Géraldine Leguelinel-BlachePharmacy Department, Nîmes University Hospital, University of Montpellier, Nîmes, France. geraldine.leguelinel@chu-nimes.fr.
Sophie BouvetInstitute Desbrest of Epidemiology and Public Health, University of Montpellier, INSERM, Montpellier, France.
Pierrick BedouchUMR 5525, University of Grenoble Alpes, CNRS, Grenoble INP, TIMC, VetAgro Sup, 38000, Grenoble, France.
Bérengère BacheletPharmacy Department, Toulouse University Hospital, Toulouse, France.
Catherine ChenaillerPharmacy Department, Rouen University Hospital, Rouen, France.
Thomas DantinPharmacy Department, Nice University Hospital, Nice, France.
Laure GenelettiPharmacy Department, Grenoble Alpes University Hospital, University of Grenoble Alpes, Grenoble, France.
Alexia JanesPharmacy Department, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Florence ScherPharmacy Department, Strasbourg University Hospital, Strasbourg, France.
Bogdan CireașăPharmacy Department, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Jean-Marie KinowskiPharmacy Department, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Christel CastelliDepartment of Law and Health Economics, Faculty of Pharmacy, University of Montpellier, Montpellier, France.
Clarisse Roux-MarsonPharmacy Department, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Working Group “Valorisation of Pharmacist Interventions” of the French Society of Clinical Pharmacy
MEDREV working group

Funding

Ministère des Affaires Sociales et de la Santé 14-0208/2014
6 · The paper itself

Abstract

backgroundImproving medication safety implies patient-centred multidisciplinary cooperation. During the hospital stay for an acute care episode, the patient needs a comprehensive management to guarantee the best possible outcome.

methodsThe study was designed as a non-blinded, multicentre stepped-wedge cluster randomised clinical trial, taking place in six French University Hospitals. Each cluster began with the control period in which standard care did not include pharmaceutical intervention. Every 14-day period, one hospital unit was electronically randomised to switch to the intervention period until all cluster groups received the intervention, which consisted of collaborative pharmaceutical care (CPC) associating medication reconciliation at hospital admission, pharmaceutical analysis of the medication order, medication review and collaborative meeting. The primary outcome was assessing the intervention through the rate of patients with at least one medication error (ME) on the admission medication order (such as omission, wrong dose or wrong route of administration), comparing the two periods.

resultsCPC decreased the rate of patients with at least one ME from 88.9% (n = 243) to 29.2% (n = 267) (p < 0.0001). A total of 1817 MEs were discovered, of which 1121 (61.7%) were in the control period and 696 (38.3%) in the intervention period before resolution by the CPC. After resolving 567 of them, 129 medication errors still remained after CPC. So, a median of 3 MEs [IQR = 1;6] per patient were detected in the control period vs 0 [IQR = 0;1] after CPC in the intervention period (p < 0.0001). Patients were 21-times more likely to avoid a ME with CPC (OR: 20.8 [8.3;52.2], p < 0.0001). The rate of patients with a 2-3 critical ME level decreased from 70.8% to 12.0% in the control vs intervention periods respectively (OR: 18.4 [7.7;43.9], p < 0.0001).

conclusionsCPC can prevent the occurrence of MEs and thus can improve inpatients' medication management and safety. Pharmacists play a key role in combating medication-related harm in healthcare settings.

trial registrationThis study is registered on ClinicalTrials.gov with the reference number NCT02598115 (2015-11-04).

Indexed as

Cooperative BehaviorInpatientsMedication ErrorsMedication ReconciliationPatient SafetyPharmacy Service, HospitalAgedAged, 80 and overCluster AnalysisFemaleHospitalizationHumansMaleClinical pharmacyCollaborative patient managementGeriatricsMedication error

Identifiers

PMID40646458
PMCPMC12247195

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.