ReviewJournal of nanobiotechnology2025
Extracellular vesicles derived from Schwann cells to enhance bone and dental tissue regeneration: a literature review.
Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dental pulp cell-derived conditioned culture media promotes periodontal repair through immunomodulation and bone regeneration.Regenerative therapy · 2026Article
- Innovative 3D-bioprinted microfibers in calcium phosphate cement platform with Nell-1 to activate nerve-bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration.Smart molecules : open access · 2026Article
- Nanotherapeutic strategy via ADSC-mitoEVs rescues ischaemic angiogenesis through mitophagy and mitochondrial metabolic reprogramming.Journal of nanobiotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundRecently, the importance and innovative applications of extracellular vesicles in bone and dental pulp tissue engineering have attracted more attention. Moreover, the use of extracellular vesicles derived from various cell types, such as mesenchymal stem cells, has been extensively examined. However, the understanding of the intricate mechanisms, diverse applications, and potential uses of extracellular vesicles originating from Schwann cells in neurogenesis, angiogenesis, neurovascularized osteogenesis, and dental pulp regeneration remains largely unexplored and under-investigated. This is the first review to provide a comprehensive overview of the cutting-edge researches on Schwann cell-derived extracellular vesicles (SCs-EVs) in the context of tissue regeneration. It emphasizes the emerging understanding of key bioactive molecules in SCs-EVs, including RNAs and proteins, and their role in promoting tissue regeneration. Furthermore, this review describes for the first time how bioactive molecules achieve neurogenic, angiogenic, osteogenic and odontogenic efficacy by activating related mechanistic pathways. In addition to these insights, the review also generalizes the potential clinical applications of SCs-EVs, both in the present and looking forward to future advancements in the field.
conclusionsSCs-EVs exhibit an impressive and effective capability for the delivery of RNAs and proteins, which play a crucial role in activating multiple biological mechanisms. Their remarkable combination with a diverse array of materials has demonstrated significant potential for facilitating tissue repair and regeneration across various biological systems. This review meticulously summarizes the various types of RNAs, proteins, and the related mechanisms that contribute to essential processes such as neurogenesis, angiogenesis, osteogenesis, and odontogenesis, highlighting their importance in regenerative medicine. Furthermore, we delve into the forefront of research and the potential applications of SCs-EVs specifically in the context of bone and dental tissue regeneration. The recent advancements in the development of SCs-EVs, alongside innovative biomaterial scaffolds, present a promising and transformative approach to enhancing therapeutic effectiveness in the regeneration of nerve, vascular, bone, and dental tissues, paving the way for future breakthroughs in regenerative therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.