Evidence mapPaperPMID 40647182Full record

ArticleNutrients2025

Red Blood Cell Omega-6 Fatty Acids and Biomarkers of Inflammation in the Framingham Offspring Study.

Heidi T M Lai, Nathan A Ryder, Nathan L Tintle, Kristina H Jackson, Penny M Kris-Etherton, William S Harris

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heidi T M LaiFatty Acid Research Institute, Sioux Falls, SD 57106, USA.ORCID 0000-0001-5540-6612
Nathan A RyderFatty Acid Research Institute, Sioux Falls, SD 57106, USA.
Nathan L TintleFatty Acid Research Institute, Sioux Falls, SD 57106, USA.
Kristina H JacksonFatty Acid Research Institute, Sioux Falls, SD 57106, USA.ORCID 0000-0003-3445-8370
Penny M Kris-EthertonFatty Acid Research Institute, Sioux Falls, SD 57106, USA.
William S HarrisFatty Acid Research Institute, Sioux Falls, SD 57106, USA.

Funding

NHLBI NIH HHS R01 HL089590NIH HHS R01 HL089590Soy Nutrition Institute N/A
6 · The paper itself

Abstract

BACKGROUND/

objectivesChronic inflammation is recognized as an important risk factor for a variety of health disorders. Omega-6 polyunsaturated fatty acids (

methodsWe included 2777 participants (mean age: 66 ± 9 years, 54% women, 9.8% minorities) from the Framingham Offspring and minority-enriched Omni cohorts, and calculated partial correlation coefficients.

resultsAfter multivariable adjustment, RBC LA was inversely correlated (all

conclusionsIn our large community-based study, we observed weak but statistically significant inverse associations between several types of inflammatory biomarkers with RBC

Indexed as

ErythrocytesFatty Acids, Omega-6InflammationAgedArachidonic AcidBiomarkersC-Reactive ProteinFemaleHumansIntercellular Adhesion Molecule-1Interleukin-6Linoleic AcidMaleMiddle AgedArachidonic AcidBiomarkersC-Reactive ProteinFatty Acids, Omega-6Intercellular Adhesion Molecule-1Interleukin-6Linoleic Acidarachidonic acidC-reactive proteininflammatory markersintercellular adhesion molecule-1interleukin-6linoleic acidmonocyte chemoattractant protein-1osteoprotegerinP-selectin

Identifiers

PMID40647182
PMCPMC12251348

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.