Evidence map›Paper›PMID 40647337›Full record

ArticleNutrients2025

Dysregulation of Arachidonic Acid Metabolism Drives Inflammatory Lipid Production in Localized Provoked Vulvodynia.

Sarah A Fischer, Oluwademilade Oladele, Zahra Mahamed, Emanuelle Chrysilla, Anna Baumer, Tamari Bekauri, Krishna Rao Maddipati, Tanzy Love, Mitchell Linder, Megan Falsetta

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah A FischerDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.
Oluwademilade OladeleDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.
Zahra MahamedDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.
Emanuelle ChrysillaDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0003-1739-4029
Anna BaumerDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.
Tamari BekauriDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0002-3522-1757
Krishna Rao MaddipatiLipidomics Core Facility and Bioactive Lipids Research Program, Wayne State University, Detroit, MI 48202, USA.
Tanzy LoveDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0002-7154-0229
Mitchell LinderDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0003-1231-7489
Megan FalsettaDepartment of Obstetrics and Gynecology, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0001-6341-3791

Funding

Mechanisms of vulvodynia involving dysregulation of pro-resolving lipidsR01HD092334 · NICHD · UNIVERSITY OF ROCHESTER · PI HAIDARIS, CONSTANTINE G, WOOD, MEGAN LINDSAY FALSETTA · 2018 to 2022
$2.4M
Transient Vanilloid Receptors and Vulvar Pain: New Therapeutic Targets for VulvodyniaR01HD108173 · NICHD · UNIVERSITY OF ROCHESTER · PI Megan Lindsay Falsetta Wood · 2023 to 2026
$2.3M
Linear Ion Trap - Quadrupole LC-MS SystemS10OD032292 · OD · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2022 to 2022
$592k
Triple Quadrupole - Ion Trap Hybrid LC/MS/MS SystemS10RR027926 · NCRR · WAYNE STATE UNIVERSITY · PI MADDIPATI, KRISHNARAO · 2010 to 2010
$425k
NICHD NIH HHS R01 HD092334NICHD NIH HHS R01 HD108173NIH HHS S10OD032292NIH HHS S10RR027926
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Arachidonic AcidInflammationLipid MetabolismVulvodyniaAdultCyclooxygenase 1Cyclooxygenase 2DinoprostoneFemaleFibroblastsHumansInflammation MediatorsInterleukin-6Linoleic AcidMiddle AgedArachidonic AcidCyclooxygenase 1Cyclooxygenase 2DinoprostoneInflammation MediatorsInterleukin-6Linoleic Acid12-LOXarachidonic acidchronic painCOX-1COX-2inflammationlipid metabolismlocalized provoked vulvodyniaspecialized pro-resolving mediators

Identifiers

PMID40647337
PMCPMC12251515

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.