Evidence map›Paper›PMID 40647378›Full record

ReviewCancers2025

Neoadjuvant, Perioperative, and Adjuvant Immunotherapy in Early-Stage Surgically Resectable Non-Small Cell Lung Cancer: Updates and Future Perspectives.

Diamone Gathers, Cameron Oswalt, Laura Alder, Kevin Chen, Jordyn P Higgins, Jeffrey M Clarke, Eziafa I Oduah

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diamone GathersDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.
Cameron OswaltDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-4293-8000
Laura AlderDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-2228-4094
Kevin ChenLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA.ORCID 0000-0002-8134-3376
Jordyn P HigginsDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.
Jeffrey M ClarkeDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.
Eziafa I OduahDuke University Health Systems, School of Medicine, Duke University, Durham, NC 27708, USA.ORCID 0000-0001-8517-6360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Historically, systemic therapy for resectable non-small cell lung cancer (NSCLC) has been associated with a modest impact on overall survival. The current treatment options for early-stage resectable NSCLC include neoadjuvant, adjuvant, and perioperative immunotherapy in combination with chemotherapy. In this review, we explore the current treatment paradigms and emerging opportunities for improved survival outcomes from using immunotherapeutic approaches in the treatment of early-stage resectable NSCLC. The incorporation of immunotherapy into neoadjuvant, adjuvant, and perioperative treatment of surgically resectable NSCLC has yielded improved outcomes beyond chemotherapy-alone approaches. Despite this, there remains a margin for improving survival outcomes for patients. Clinical trials utilizing novel agents and approaches that modulate the anti-tumor immune response are currently ongoing and will likely inform the future treatment landscape for early-stage surgically resectable NSCLC.

Indexed as

adjuvantearly-stage NSCLCimmunotherapyneoadjuvantnon-small cell lung cancer (NSCLC)perioperative

Identifiers

PMID40647378
PMCPMC12248727

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.