Evidence map›Paper›PMID 40647474›Full record

ArticleCancers2025

Advancing the Landscape of Clinical Actionability in Von Hippel-Lindau Syndrome: An Evidence-Based Framework from the INT

Diane R Koeller, McKenzie Walker, Busra Unal, Anu Chittenden, Alison Schwartz Levine, Connor P Hayes, Paul C Oramasionwu, Monica D Manam, Ryan M Buehler, Israel Gomy and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Diane R KoellerDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-1217-9514
McKenzie WalkerDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.
Busra UnalDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.
Anu ChittendenDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Alison Schwartz LevineDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-3861-4203
Connor P HayesDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.
Paul C OramasionwuDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.
Monica D ManamBoston Children's Hospital, Boston, MA 02115, USA.ORCID 0009-0003-3408-1718
Ryan M BuehlerDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Israel GomyDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-902, Brazil.ORCID 0000-0002-7926-8477
Wilson Araujo SilvaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-902, Brazil.ORCID 0000-0001-9364-2886
Jordan Lerner-EllisPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0003-3685-5679
Selina CasalinoPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Radhika MahajanPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0009-0001-0861-7748
Nicholas WatkinsPathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Nihat Bugra AgaogluDivision of Cancer Genetics, Umraniye Training and Research Hospital, 34764 Istanbul, Turkey.
Danielle K ManningDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Justine A BarlettaDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jason L HornickDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-6475-8345
Neal I LindemanPathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Huma Q RanaDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-1598-6752
Judy E GarberDivision of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0001-9449-3982
Arezou A GhazaniDivision of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-4439-8554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

INT2GRATE Oncology ConsortiumINT2GRATE variant portalsomatic and germline integrationVHLVon Hippel–Lindau Syndrome

Identifiers

PMID40647474
PMCPMC12248699

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.