Evidence map›Paper›PMID 40647499›Full record

ReviewCancers2025

Breaking Dogmas in Axillary Lymphadenectomy and Quality of Life.

Sandra López Gordo, Jaime Jimeno-Fraile, Anna García-Monferrer, Pau Nicolau, Neus Ruiz-Edo, Elena Ramirez-Maldonado, Santiago Rojas, Cristina Serra-Serra

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandra López GordoGeneral and Digestive Surgery Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.ORCID 0000-0001-9558-0041
Jaime Jimeno-FraileBreast Unit, General and Digestive Surgery, Marqués de Valdecilla, 39008 Santander, Spain.ORCID 0000-0002-2665-2571
Anna García-MonferrerGeneral and Digestive Surgery Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.
Pau NicolauGinecology Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.ORCID 0000-0002-6958-4054
Neus Ruiz-EdoGeneral and Digestive Surgery Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.
Elena Ramirez-MaldonadoGeneral and Digestive Surgery Department, Universitary Hospital of Tarragona Joan XXIII, 43005 Tarragona, Spain.
Santiago RojasUnit of Human Anatomy and Embriology, Department of Morphological Sciences, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.
Cristina Serra-SerraGinecology Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Axillary lymph node dissection (ALND), although increasingly less necessary, is still required in specific breast cancer surgery scenarios, such as cases with a high axillary tumor burden. However, traditional practices are being reassessed due to the associated morbidity and impacts on recovery. This review explores five critical and controversial innovations in ALND: (1) same-day discharge, (2) omission of surgical drains, (3) application of fibrin sealants, (4) minimally invasive techniques, and (5) their collective influence on quality of life (QoL). Same-day discharge has proven to be safe and cost-effective, increasing patient satisfaction without raising complication rates. The omission of drains, while slightly increasing seroma volumes, is linked to shorter hospital stays and fewer complications. The use of fibrin sealants shows promising results in reducing the seroma volume and duration, expediting recovery, although their routine use remains under debate. Minimally invasive and endoscopic techniques reduce morbidity and improve cosmetic outcomes while maintaining oncological safety. Quality of life (QoL) is essential in the evaluation of breast cancer treatment and is evaluated using tools such as EORTC QLQ-C30, QLQ-BR23, and FACT-B, SF-36, which assess physical, emotional, and psychosocial recovery. Innovations in ALND seem to improve QoL by minimizing pain, increasing arm function, and reducing psychological stress, underscoring the importance of patient-centered strategies. Although axillary lymphadenectomy increases arm morbidity compared to sentinel node biopsy, its overall impact on quality of life appears limited, likely due to the overlapping effects of systemic therapies and breast surgery.

Indexed as

ambulatoryaxillary lymphadenectomybreast cancerdrainminimal invasive surgeryquality of lifesealant

Identifiers

PMID40647499
PMCPMC12249132

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.