Evidence map›Paper›PMID 40647526›Full record

ReviewCancers2025

Impact of Proton Pump Inhibitor Use on Progression-Free and Overall Survival in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy: A Systematic Review and Meta-Analysis of Recent Studies.

Giuliana Ciappina, Alessandro Ottaiano, Mariachiara Santorsola, Emanuela Esposito, Fabiola De Luca, Carlotta Giorgi, Concetta Zito, Anna Paola Capra, Patrizia Carroccio, Nicola Maurea and 7 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Fusobacterium nucleatum, succinate signaling, and immunotherapy resistance in colorectal cancer: clinical relevance and translational opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giuliana CiappinaDepartment of Medical Sciences, Section of Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0813-3126
Alessandro OttaianoDivision of Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0002-2901-3855
Mariachiara SantorsolaDivision of Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Naples, Italy.
Emanuela EspositoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0002-2663-6387
Fabiola De LucaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0009-0000-3431-9421
Carlotta GiorgiLaboratory for Technologies of Advanced Therapies (LTTA), Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, 48033 Ferrara, Italy.ORCID 0000-0002-2494-7405
Concetta ZitoCardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy.ORCID 0000-0002-6908-4316
Anna Paola CapraDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0002-1428-3609
Patrizia CarroccioSchool of Specialization in Medical Oncology, Department of Human Pathology "G. Barresi", University of Messina, 98125 Messina, Italy.ORCID 0009-0008-0529-0816
Nicola MaureaDivision of Cardiology, Istituto Nazionale Tumori-IRCSS-Fondazione G. Pascale, 80131 Naples, Italy.ORCID 0000-0003-3704-0092
Vincenzo QuagliarielloDivision of Cardiology, Istituto Nazionale Tumori-IRCSS-Fondazione G. Pascale, 80131 Naples, Italy.
Irene CampoSchool of Specialization in Medical Oncology, Department of Human Pathology "G. Barresi", University of Messina, 98125 Messina, Italy.
Maria Ilenia PassalacquaDivision of Medical Oncology, AOU "G.Martino" Hospital, University of Messina, 98166 Messina, Italy.ORCID 0000-0003-4039-8255
Dalila IncognitoSchool of Specialization in Medical Oncology, Department of Human Pathology "G. Barresi", University of Messina, 98125 Messina, Italy.
Irene CacciolaDepartment of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy.ORCID 0000-0001-7721-6799
Pierluigi ConsoloDepartment of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy.
Massimiliano BerrettaDivision of Medical Oncology, AOU "G.Martino" Hospital, University of Messina, 98166 Messina, Italy.ORCID 0000-0002-9837-9148

Funding

Italian National Recovery and Resilience Plan (PNRR), European Union - NextGenerationEU PNRR-MCNT1-2023-12378355
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

immune checkpoint inhibitorsimmunotherapymicrobiotaPPIsproton-pump inhibitorssolid tumors

Identifiers

PMID40647526
PMCPMC12248532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.