Understanding Anti-Obesity Potential of Four Porphyrin Compounds by Investigating Pancreatic Lipase Inhibition.

Jie Zhou, Xinrui Wang, Yangyuxin Liu, Xiaochen Li, Mingze Huang, Helong Bai, Jingang Mo

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jie ZhouCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Xinrui WangCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Yangyuxin LiuCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Xiaochen LiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Mingze HuangCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Helong BaiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.ORCID 0009-0006-7988-9202

Jingang MoCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Funding

the Science and Technology Development Plan Project of Jilin Province, China YDZJ202201ZYTS658

6 · The paper itself

Abstract

Obesity is a chronic epidemic caused by abnormal fat metabolism. As a key digestive enzyme, pancreatic lipase (PL) is an important target for regulating fat metabolism. The inhibitory potential of 5,10,15,20-Tetrakis (4-aminophenyl) porphyrin (TAPP), 5,10,15,20-Tetrakis (4-hydroxyphenyl) porphyrin (THPP), meso-Tetra (4-carboxyphenyl) porphine (TCPP), Cu (II) meso-Tetra (4-carboxyphenyl) porphine (Cu-TCPP) on PL was studied by enzymatic kinetics, multi-spectral, and molecular simulation technology. THPP, TCPP, TAPP, and Cu-TCPP all had good PL inhibitory activity (IC

Indexed as

Anti-Obesity AgentsEnzyme InhibitorsLipasePancreasPorphyrinsHumansKineticsMolecular Docking SimulationMolecular Dynamics SimulationAnti-Obesity AgentsEnzyme InhibitorsLipasePorphyrinsinhibitionpancreatic lipaseporphyrin compound

Identifiers

PMID40649221

DOI10.3390/molecules30132701

PMCPMC12251151

What Socratic holds

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LicenceCC BY

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