Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3',5'-

Xiaosong He, Jiahao Yi, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Synthesis and evaluation of vanillin-based sulfonates as potent α-glucosidase inhibitors through in vitro, in vivo, and in silico approaches.Scientific reports · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaosong HeDepartment of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.

Jiahao YiDepartment of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.

Jianchen YangDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.

Genzoh TanabeSchool of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiosaka 577-8502, Osaka, Japan.

Osamu MuraokaSchool of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiosaka 577-8502, Osaka, Japan.

Weijia XieDepartment of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.

Funding

National Key R&D Program of China 2022YFE0105400

6 · The paper itself

Abstract

A group of sulfonium and selenonium salts bearing diverse benzylidene acetal substituents on their side chain moiety were designed and synthesized. Compared with our previous study, structural modifications in this study focused on multi-substitution of the phenyl ring and bioisosteric replacements at the sulfonium cation center. In vitro biological evaluation showed that selenonium replacement could significantly improve their α-glucosidase inhibitory activity. The most potent inhibitor

Indexed as

alpha-GlucosidasesBenzylidene CompoundsDrug DesignGlycoside Hydrolase InhibitorsSulfonium CompoundsAnimalsHumansKineticsMiceMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesBenzylidene CompoundsGlycoside Hydrolase InhibitorsSulfonium Compoundsanti-hyperglycemic effectsSalaciaselenonium saltssulfonium saltsα-glucosidase inhibitor

Identifiers

PMID40649370

DOI10.3390/molecules30132856

PMCPMC12250965

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.