Evidence map›Paper›PMID 40649713›Full record

ArticleInternational journal of molecular sciences2025

Hippo Pathway Dysregulation in Thymic Epithelial Tumors (TETs): Associations with Clinicopathological Features and Patients' Prognosis.

Lisa Elm, Nadja Gerlitz, Anke Hochholzer, Thomas Papadopoulos, Georgia Levidou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lisa ElmDepartment of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany.
Nadja GerlitzDepartment of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany.
Anke HochholzerDepartment of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany.
Thomas PapadopoulosDepartment of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany.
Georgia LevidouDepartment of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany.ORCID 0000-0002-1398-178X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymic epithelial tumors (TETs) display heterogeneous histology and often unpredictable clinical behavior. The Hippo signaling pathway has been implicated in tumorigenesis, but its role in TETs remains poorly characterized. We performed the first comprehensive immunohistochemical analysis of core and upstream Hippo pathway components-YAP1, active YAP (AYAP), TAZ, LATS1, MOB1A, MST1, SAV1, and TEAD4-in 77 TETs. Associations with clinicopathological parameters and survival were explored. We observed widespread expression of Hippo components in TETs with significant associations among molecules and differences in subcellular localization and expression in normal tissue. Early stage TETs showed higher nuclear YAP1 (

Indexed as

Neoplasms, Glandular and EpithelialProtein Serine-Threonine KinasesSignal TransductionThymus NeoplasmsAdaptor Proteins, Signal TransducingAdultAgedDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHippo Signaling PathwayHumansMaleMiddle AgedMuscle ProteinsPrognosisAdaptor Proteins, Signal TransducingDNA-Binding ProteinsMuscle ProteinsProtein Serine-Threonine KinasesTEAD4 protein, humanTEA Domain Transcription FactorsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinshippo signaling pathwayimmunohistochemistryTETsthymic epithelial tumors

Identifiers

PMID40649713
PMCPMC12250049

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.