Evidence map›Paper›PMID 40649740›Full record

ReviewInternational journal of molecular sciences2025

Ovarian Cancer: Multi-Omics Data Integration.

Anna Kliuchnikova, Arina Gordeeva, Aziz Abdurakhimov, Tatiana Materova, Svetlana Tarbeeva, Elizaveta Sarygina, Anna Kozlova, Olga Kiseleva, Elena Ponomarenko, Ekaterina Ilgisonis

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Protein Variability Patterns in Ovarian Serous Carcinoma.International journal of molecular sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna KliuchnikovaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0001-9230-1238
Arina GordeevaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.
Aziz AbdurakhimovInstitute of Biomedical Chemistry, 119121 Moscow, Russia.
Tatiana MaterovaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.
Svetlana TarbeevaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.
Elizaveta SaryginaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0002-2261-2038
Anna KozlovaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0002-2147-6679
Olga KiselevaInstitute of Biomedical Chemistry, 119121 Moscow, Russia.ORCID 0000-0003-3032-1983
Elena PonomarenkoInstitute of Biomedical Chemistry, 119121 Moscow, Russia.
Ekaterina IlgisonisInstitute of Biomedical Chemistry, 119121 Moscow, Russia.

Funding

Russian Science Foundation 24-74-10098
6 · The paper itself

Abstract

This study focuses on the systematization and integration of ovarian cancer multi-omics data, revealing patterns in the application of different omics-based approaches and assessing factors that affect the identification of potential biomarkers. An integrative analysis of 51 publications revealed 1649 potential biomarkers. The findings emphasized the molecular diversity of ovarian cancer. They demonstrated the importance of performing the comprehensive integration of molecular and clinical data to search for diagnostic alternatives and molecular patterns underlying ovarian cancer. The heterogeneity of data sources, differences in data acquisition and analysis protocols, and the lack of uniform standards affect the reproducibility of the results of genomic and post-genomic profiling. Multi-omics studies are more promising than mono-omics-based ones. Despite technological advances, researchers continue to focus on results obtained over a decade ago, which may hinder the scientific community from exploring new horizons in ovarian cancer research.

Indexed as

GenomicsOvarian NeoplasmsProteomicsBiomarkers, TumorComputational BiologyFemaleHumansMetabolomicsMultiomicsBiomarkers, Tumorbiomarkersmolecular heterogeneitymulti-omicsomicsovarian carcinomapersonalized therapy

Identifiers

PMID40649740
PMCPMC12249510

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.