Tetrahydrocurcumin Outperforms Curcumin in Preventing Oxidative Stress-Induced Dysfunction in Tert-Butyl Hydroperoxide-Stimulated Cardiac Fibroblasts.

Patrícia Dos Santos Azeredo, Charity Fix, Laena Pernomian, Camilla F Wenceslau, Gerardo G Piroli, Cristina Pontes Vicente, Wayne E Carver

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patrícia Dos Santos AzeredoDepartment of Molecular and Morphofunctional Biology, State University of Campinas, Campinas 13083-865, SP, Brazil.ORCID 0000-0001-8131-253X

Charity FixDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.ORCID 0009-0000-9768-7475

Laena PernomianDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.ORCID 0000-0003-3930-0919

Camilla F WenceslauDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.ORCID 0000-0002-0815-3568

Gerardo G PiroliDepartment of Pharmacology, Physiology & Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.ORCID 0009-0004-1656-5492

Cristina Pontes VicenteDepartment of Molecular and Morphofunctional Biology, State University of Campinas, Campinas 13083-865, SP, Brazil.

Wayne E CarverDepartment of Cell Biology and Anatomy, Cardiovascular Translational Research Center, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.

Funding

Alzheimer`s Association AARG-NTF-23-1145090Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001National Institutes of Health (NIH) R01HL149762 and R21AG085331-01

6 · The paper itself

Abstract

Oxidative stress is a common feature of various pathological conditions, including tissue remodeling and dysfunction. Cardiac fibroblasts, which play a key role in maintaining extracellular matrix homeostasis, are sensitive to oxidative injury. Curcumin and tetrahydrocurcumin are plant-derived polyphenols with antioxidant properties, yet their relative efficacy in preventing oxidative stress-induced dysfunction in cardiac fibroblasts remains unclear. In this study, cardiac fibroblasts were treated with curcumin or tetrahydrocurcumin prior to exposure to tert-butyl hydroperoxide (t-BHP), a widely used inducer of oxidative stress. Cell viability, apoptosis, reactive oxygen species (ROS) production, and

Indexed as

AntioxidantsCurcuminFibroblastsMyocardiumOxidative Stresstert-ButylhydroperoxideAnimalsApoptosisCells, CulturedCell SurvivalRatsReactive Oxygen SpeciesTransforming Growth Factor beta1AntioxidantsCurcuminReactive Oxygen Speciestert-ButylhydroperoxidetetrahydrocurcuminTransforming Growth Factor beta1apoptosiscardiac fibroblastscurcuminoxidative stresstetrahydrocurcuminTgfb1

Identifiers

PMID40649742

DOI10.3390/ijms26135964

PMCPMC12250096

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.