Evidence map›Paper›PMID 40649746›Full record

ArticleInternational journal of molecular sciences2025

Combinatorial Effects of CPP-Modified Antimicrobial Peptides: Synergistic and Additive Interactions Against Pathogenic Bacteria.

Oxana V Galzitskaya, Sergey V Kravchenko, Sergei Y Grishin, Alena P Zakhareva, Leila G Mustaeva, Elena Y Gorbunova, Alexey K Surin, Viacheslav N Azev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oxana V GalzitskayaGamaleya Research Centre of Epidemiology and Microbiology, Moscow 123098, Russia.ORCID 0000-0002-3962-1520
Sergey V KravchenkoInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, Tyumen 625003, Russia.ORCID 0000-0002-1261-7919
Sergei Y GrishinInstitute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Russia.ORCID 0000-0001-7373-9808
Alena P ZakharevaInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, Tyumen 625003, Russia.
Leila G MustaevaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.
Elena Y GorbunovaThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.
Alexey K SurinInstitute of Environmental and Agricultural Biology (X-BIO), Tyumen State University, Tyumen 625003, Russia.ORCID 0000-0001-9246-7369
Viacheslav N AzevThe Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Russia.ORCID 0000-0003-3275-4811

Funding

the Ministry of Science and Higher Education of the Russian Federation 075-15-2024-563
6 · The paper itself

Abstract

The development of novel antimicrobial peptides (AMPs) with broad-spectrum activity represents a promising strategy to overcome multidrug resistance in pathogenic bacteria. In this study, we investigated the antimicrobial activity of three designed peptides-R44K

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacteriaCell-Penetrating PeptidesBacillus cereusDrug SynergismEscherichia coliHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcus aureusAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCell-Penetrating Peptidesamyloidogenic regionsantimicrobial peptidesAntp fragmentcell-penetrating peptideMRSApeptide synergyTAT fragment

Identifiers

PMID40649746
PMCPMC12250457

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.