Evidence mapPaperPMID 40649774Full record

ReviewInternational journal of molecular sciences2025

Echocardiographic Assessment of Cardiac Function in Mouse Models of Heart Disease.

Nadia Salerno, Assunta Di Costanzo, Fabiola Marino, Mariangela Scalise, Isabella Leo, Jolanda Sabatino, Giovanni Canino, Antonio Leccia, Antonella De Angelis, Konrad Urbanek and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. An Integrated Evaluation Framework for Adult Heart Regeneration.Journal of cellular and molecular medicine · 2026
    Article
  4. Article
  5. Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nadia SalernoDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Assunta Di CostanzoDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0009-0007-9963-6402
Fabiola MarinoDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0001-9043-6032
Mariangela ScaliseDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Isabella LeoDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-4774-0888
Jolanda SabatinoDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Giovanni CaninoDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Antonio LecciaCardiology Complex Unit, ASL Napoli 2 Nord "San Giovanni di Dio" Hospital, 80027 Frattamaggiore, Italy.
Antonella De AngelisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Konrad UrbanekDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0001-6359-0974
Daniele TorellaDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-4915-5084
Eleonora CianfloneDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-1675-2093

Funding

Italian Ministry of Health PSC SALUTE 2014-2020 - POS4 "Cal-Hub-Ria" (T4-AN-09), and PNRR MAD-2022-12376814".Italian Ministry of University and Research PRIN 2020L45ZWA_005, PRIN-PNRR 2022: P2022NRRB8; PRIN 2020L45ZW4_005 and PNRR-National Center for Gene Therapy and Drugs based on RNA Technology (CN00000041)
6 · The paper itself

Abstract

Echocardiography is a cornerstone technique for evaluating cardiac function in preclinical research using murine models. This review provides a comprehensive overview of the echocardiographic approaches employed to assess ventricular function in mouse models of heart disease, highlighting methodological principles, technical challenges, and the translational relevance of findings. Various echocardiographic modalities enable the precise evaluation of systolic and diastolic function. This article emphasizes standardization in image acquisition and analysis to minimize inter-operator variability and ensure reproducibility. It details echocardiographic parameters and strain imaging across commonly used mouse models of non-ischemic dilated cardiomyopathy, diabetic cardiomyopathy, hypertensive heart disease, and ischemic heart disease. Furthermore, it explores the advantages and limitations of anesthesia, probe positioning, and physiological monitoring during imaging. The integration of advanced imaging technologies such as Speckle-Tracking Echocardiography (STE), Three-Dimensional (3-D), and Four-Dimensional (4-D) echocardiography is discussed as a promising avenue for enhancing data quality and improving the translational potential of preclinical cardiac studies.

Indexed as

EchocardiographyHeartHeart DiseasesAnimalsDisease Models, AnimalHumansMicecardiac imagingechocardiographyheart failuremicesmall animals

Identifiers

PMID40649774
PMCPMC12249879

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.