Evidence map›Paper›PMID 40649775›Full record

ArticleInternational journal of molecular sciences2025

Association of Tissue Expression of LAG-3 and TIM-3 with Clinical Features in Ovarian Cancer.

Dominika Borzyszkowska, Mateusz Kozłowski, Anna Golara, Katarzyna Piotrowska, Agnieszka Brodowska, Jacek Brodowski, Iwona Bojar, Agnieszka Kempinska-Podhorodecka, Aneta Cymbaluk-Płoska

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dominika BorzyszkowskaDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0001-6259-5052
Mateusz KozłowskiDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-1176-2153
Anna GolaraDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0003-4300-4557
Katarzyna PiotrowskaDepartment of Physiology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-4472-0830
Agnieszka BrodowskaDepartment of Gynecology, Endocrinology and Gynecologic Oncology, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0002-6425-1648
Jacek BrodowskiPrimary Care Department, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland.ORCID 0000-0002-6853-9155
Iwona BojarDepartment of Women's Health, Institute of Rural Health, 20-093 Lublin, Poland.ORCID 0000-0002-3171-225X
Agnieszka Kempinska-PodhorodeckaDepartment of Medical Biology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-7513-8640
Aneta Cymbaluk-PłoskaDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most prevalent types of cancer among women is ovarian cancer. The search for ovarian cancer markers is constantly ongoing. Evaluation of LAG-3 and TIM-3 protein expression in ovarian cancer tissue and its role in distinguishing the clinical signs stated were the objectives of this study. Methods: A total of 58 ovarian cancer patients were recruited for this study. The cohort was split into two groups: one for high-grade serous ovarian cancer (HGSOC) and another for ovarian cancer that was not HGSOC (non-HGSOC). LAG-3 and TIM-3 protein expression in ovarian cancer tissue samples was evaluated by immunohistochemistry. StatView 5.0 software (Carry, NC, USA) was used for all statistical analyses. Both LAG-3 and TIM-3 proteins mostly showed positive, moderately positive, or strongly positive expression. This study shows that LAG-3 could be a marker associated with BMI in the non-HGSOC group. TIM-3 may be a marker associated with age in a group of all ovarian cancers. LAG-3 expression is associated with TIM-3 expression in the total cohort and the HGSOC and non-HGSOC groups.

Indexed as

Biomarkers, TumorHepatitis A Virus Cellular Receptor 2Ovarian NeoplasmsAdultAgedFemaleHumansImmunohistochemistryLymphocyte Activation Gene 3 ProteinMiddle AgedBiomarkers, TumorHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Lag3 protein, humanLymphocyte Activation Gene 3 ProteinexpressionHGSOCimmune biomarkerLAG-3markerovarian cancerTIM-3

Identifiers

PMID40649775
PMCPMC12249942

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.