Evidence map›Paper›PMID 40649839›Full record

ArticleInternational journal of molecular sciences2025

Pharmacological Preconditioning with Diazoxide Upregulates HCN4 Channels in the Sinoatrial Node of Adult Rat Cardiomyocytes.

Wilibaldo Orea, Elba D Carrillo, Ascención Hernández, Rubén Moreno, María C García, Jorge A Sánchez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wilibaldo OreaDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Elba D CarrilloDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Ascención HernándezDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Rubén MorenoDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
María C GarcíaDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Jorge A SánchezDepartment of Pharmacology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.ORCID 0000-0002-0057-435X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardioprotection against ischemia is achieved using openers of mitochondrial ATP-sensitive K

Indexed as

DiazoxideHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMyocytes, CardiacSinoatrial NodeUp-RegulationAnimalsDecanoic AcidsHeart RateHydroxy AcidsMalePotassium ChannelsRatsRats, Sprague-DawleyReactive Oxygen Species5-hydroxydecanoic acidDecanoic AcidsDiazoxideHCN4 protein, ratHydroxy AcidsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsReactive Oxygen Speciesc-FosHCN4 channelpreconditioningreactive oxygen speciessinoatrial node cells

Identifiers

PMID40649839
PMCPMC12249526

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.