Evidence mapPaperPMID 40649846Full record

ArticleInternational journal of molecular sciences2025

GSH/pH-Responsive Chitosan-PLA Hybrid Nanosystems for Targeted Ledipasvir Delivery to HepG2 Cells: Controlled Release, Improved Selectivity, DNA Interaction, Electrochemical and Stopped-Flow Kinetics Analyses.

Ahmed M Albasiony, Amr M Beltagi, Mohamed M Ibrahim, Shaban Y Shaban, Rudi van Eldik

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmed M AlbasionyAnalytical and Bioinorganic Chemistry Departments, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Amr M BeltagiAnalytical and Bioinorganic Chemistry Departments, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Mohamed M IbrahimDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Shaban Y ShabanAnalytical and Bioinorganic Chemistry Departments, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0003-3717-6803
Rudi van EldikDepartments of Chemistry and Pharmacy, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.ORCID 0000-0003-4271-0118

Funding

Taif University TU-DSPP-2024-03
6 · The paper itself

Abstract

This study aimed to design dual-responsive chitosan-polylactic acid nanosystems (PLA@CS NPs) for controlled and targeted ledipasvir (LED) delivery to HepG2 liver cancer cells, thereby reducing the systemic toxicity and improving the therapeutic selectivity. Two formulations were developed utilizing ionotropic gelation and

Indexed as

BenzimidazolesChitosanDNAFluorenesNanoparticlesPolyestersDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsDrug LiberationHep G2 CellsHumansHydrogen-Ion ConcentrationKineticsBenzimidazolesChitosanDelayed-Action PreparationsDNADrug CarriersFluorenesPolyesterspoly(lactide)chitosan nanoparticlesGSH-responsiveledipasvir repurposingpH-responsivetargeted drug deliverytherapeutic index

Identifiers

PMID40649846
PMCPMC12250219

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.