Evidence map›Paper›PMID 40649876›Full record

ArticleInternational journal of molecular sciences2025

Age-Associated Proteomic Changes in Human Spermatozoa.

Mohd Amin Beg, Abrar Osama Ismail, Ayodele Alaiya, Firdous Ahmad Khan, Taha Abo-Almagd Abdel-Meguid Hamoda, Ishfaq Ahmad Sheikh, Priyanka Sharma, Omar Mohammed Baothman, Ali Hasan Alkhzaim, Zakia Shinwari and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Age-Associated Metabolomic Changes in Human Spermatozoa.International journal of molecular sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mohd Amin BegKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-8495-4738
Abrar Osama IsmailKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ayodele AlaiyaCell Therapy & Immunobiology Department, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0003-2124-8550
Firdous Ahmad KhanDepartment of Large Animal Medicine and Surgery, School of Veterinary Medicine, St. George's University, True Blue, Grenada.ORCID 0000-0002-1903-8784
Taha Abo-Almagd Abdel-Meguid HamodaDepartment of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-8070-4088
Ishfaq Ahmad SheikhKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Priyanka SharmaCenter of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Omar Mohammed BaothmanMicrobiology and Molecular Section, Al Salama Hospital, Jeddah 23611, Saudi Arabia.
Ali Hasan AlkhzaimDepartment of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Zakia ShinwariCell Therapy & Immunobiology Department, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-7885-7034
Rinad Fahad AbuzinadahCenter of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Arif MohammedDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah 23890, Saudi Arabia.
Abdullah Mohammed AssiriDepartment of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0002-2753-5238
Adel Mohammad AbuzenadahKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Erdogan MemiliCooperative Agricultural Research Center, College of Agriculture and Human Sciences, Prairie View A&M University, Prairie View, TX 77446, USA.
Jean Magloire FeugangDepartment of Animal and Dairy Sciences, Mississippi State University, Starkville, MS 39759, USA.ORCID 0000-0002-1376-5059

Funding

Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia 1132
6 · The paper itself

Abstract

Advancing age in men significantly contributes to declining sperm fertility. Information on age-related proteomic changes in spermatozoa is limited. This study involved normal fertile Arab men in three age groups: young adult (21-30 years;

Indexed as

AgingProteomeProteomicsSpermatozoaAdultHumansMaleMiddle AgedSperm MotilityTandem Mass SpectrometryYoung AdultProteomeaginghumanLC-MS/MSproteomicsspermatozoa

Identifiers

PMID40649876
PMCPMC12249680

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.