Evidence map›Paper›PMID 40649893›Full record

ArticleInternational journal of molecular sciences2025

Novel Au(I)- and Ag(I)-NHC Complexes with

Jessica Ceramella, Assunta D'Amato, Francesca Procopio, Annaluisa Mariconda, Daniel Chavarria, Domenico Iacopetta, Francesco Ortuso, Pasquale Longo, Fernanda Borges, Maria Stefania Sinicropi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jessica CeramellaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-1386-3601
Assunta D'AmatoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0001-9246-5523
Francesca ProcopioDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Annaluisa MaricondaDepartment of Basic and Applied Sciences (DISBA), University of Basilicata, Via Dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-9763-838X
Daniel ChavarriaCIQUP-IMS-Centro de Investigação em Química da Universidade do Porto, Institute of Molecular Sciences, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.ORCID 0000-0002-7010-9808
Domenico IacopettaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0001-5179-7118
Francesco OrtusoDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0001-6235-8161
Pasquale LongoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-7685-1093
Fernanda BorgesMedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, 4200-319 Porto, Portugal.ORCID 0000-0003-1050-2402
Maria Stefania SinicropiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-2435-8931

Funding

FCT and FEDER/COMPETE CEECINSTLA/00022/2022FEDER funds through national funds by FCT - Foundation for Science and Technology UIDB/00081/2020 (https://doi.org/10.54499/UIDB/00081/2020, CIQUP) UIDP/00081/2020 (https://doi.org/10.54499/UIDP/00081/2020, CIQUP), LA/P/0056/2020 (https://doi.org/10.54499/LA/P/0056/2020, IMSPRIN 2022 2022HARH5WPRIN 2022 PNRR P20222BLAZ
6 · The paper itself

Abstract

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive neuronal dysfunction and loss and represent a significant global health challenge. Oxidative stress, neuroinflammation, and neurotransmitter dysregulation, particularly affecting acetylcholine (ACh) and monoamines, are key hallmarks of these conditions. The current therapeutic strategies targeting cholinergic and monoaminergic systems have some limitations, highlighting the need for novel approaches. Metallodrugs, especially ruthenium and platinum complexes, are gaining attention for their therapeutic use. Among metal complexes, gold(I) and silver(I)

Indexed as

Coordination ComplexesGoldHeterocyclic CompoundsMethaneNeurodegenerative DiseasesProlineSilverAcetylcholinesteraseAnimalsAnti-Inflammatory AgentsAntioxidantsCholinesterase InhibitorsHumansMonoamine OxidaseMonoamine Oxidase InhibitorsAcetylcholinesteraseAnti-Inflammatory AgentsAntioxidantscarbeneCholinesterase InhibitorsCoordination ComplexesGoldHeterocyclic CompoundsMethaneMonoamine OxidaseMonoamine Oxidase InhibitorsProlineSilveranti-inflammation propertiescholinesterase inhibitorsMAO inhibitorsneurodegenerative diseasesNHC complexesoxidative stressprolinesilver(I)/gold(I)

Identifiers

PMID40649893
PMCPMC12249917

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.