Evidence map›Paper›PMID 40649908›Full record

ArticleInternational journal of molecular sciences2025

Circadian-Tuned Peptide Drug/Gene Co-Delivery Nanocomplexes to Enhance Glioblastoma Targeting and Transfection.

Ana R Neves, Eric Vivès, Prisca Boisguérin, Telma Quintela, Diana Costa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana R NevesRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
Eric VivèsPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.ORCID 0000-0001-5391-9641
Prisca BoisguérinPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.ORCID 0000-0002-6955-1340
Telma QuintelaRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.ORCID 0000-0001-5202-9858
Diana CostaRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.ORCID 0000-0002-5049-4518

Funding

Fundação para a Ciência e a Tecnologia (FCT) 2021.03946.CEECIND Assistant Researcher Contract. A. Neves (2020.08310.BD) - FCT PhD fellowship
6 · The paper itself

Abstract

Glioblastoma is the most prevalent and aggressive form of brain malignancy. Actual treatments face several challenges due to its high aggressiveness and poor prognosis. The chemotherapeutic agent temozolomide (TMZ) has limited therapeutic efficacy, and mutations in the tumour protein p53 gene (

Indexed as

Brain NeoplasmsCell-Penetrating PeptidesCircadian RhythmDrug Delivery SystemsGene Transfer TechniquesGlioblastomaTransfectionARNTL Transcription FactorsCell Line, TumorHumansPeriod Circadian ProteinsReceptors, TransferrinTemozolomideTransferrinTumor Suppressor Protein p53ARNTL Transcription FactorsCell-Penetrating PeptidesPER2 protein, humanPeriod Circadian ProteinsReceptors, TransferrinTemozolomideTransferrinTumor Suppressor Protein p53chronotherapycircadian rhythmsdrug/gene dual therapyglioblastomananotechnologyTMZ/TP53 systems

Identifiers

PMID40649908
PMCPMC12250532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.