Soy Protein Isolate Affects Blood and Brain Biomarker Expression in a Mouse Model of Fragile X.

Brynne Boeck, Yingqing Mao, Ruo-Pan Huang, Cara J Westmark

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brynne BoeckDepartment of Neurology, University of Wisconsin, Madison, WI 53706, USA.ORCID 0009-0008-1761-278X

Yingqing MaoRayBiotech, Inc., Peachtree Corners, GA 30092, USA.ORCID 0009-0004-2193-7983

Ruo-Pan HuangRayBiotech, Inc., Peachtree Corners, GA 30092, USA.

Cara J WestmarkDepartment of Neurology, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0003-3919-3279

Funding

United States Department of Agriculture 2018-67001-28266University of Wisconsin Alumni Research Foundation Pandemic-Affected Research Continuation Initiative

6 · The paper itself

Abstract

Fragile X syndrome is characterized by the diminished expression of the fragile X messenger ribonucleoprotein (FMRP), a ubiquitously expressed RNA binding protein with numerous functions in cells. Our prior work found significant differences in physiological and behavioral outcomes as a function of FMRP levels and in response to diet in mice. Here, we assess protein biomarker levels as a function of FMRP levels, sex and matched casein and soy protein isolate-based purified ingredient diets in

Indexed as

BiomarkersBrainFragile X SyndromeSoybean ProteinsAnimalsDisease Models, AnimalFemaleFragile X Messenger Ribonucleoprotein 1MaleMiceMice, KnockoutBiomarkersFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Soybean ProteinscytokineFmrKO mousefragile X syndromesoy diet

Identifiers

PMID40649914

DOI10.3390/ijms26136137

PMCPMC12250412

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.