Evidence map›Paper›PMID 40649945›Full record

ArticleInternational journal of molecular sciences2025

Targeting Recipient Dendritic Cells with Sialic Acid-Modified Donor Alloantigen Prolongs Skin Transplant Survival.

Monica Sen, Qi Peng, Kulachelvy Ratnasothy, Martino Ambrosini, Hakan Kalay, Jordan Bazoer, Kate E Adams, Nouhad El Ouazzani, Abdessamad Ababou, David B Guiliano and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Monica SenSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.
Qi PengMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.ORCID 0000-0002-9223-5856
Kulachelvy RatnasothyMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.
Martino AmbrosiniDC4U Technologies, 3621 ZA Breukelen, The Netherlands.
Hakan KalayDepartment of Molecular Cell Biology and Immunology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, O12 Building Postbox 7057, 1007 MB Amsterdam, The Netherlands.
Jordan BazoerSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.
Kate E AdamsSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.
Nouhad El OuazzaniSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.ORCID 0009-0006-9167-3682
Abdessamad AbabouSchool of Cardiovascular Medicine and Science, King's College London, London SE1 1UL, UK.ORCID 0000-0003-2307-5489
David B GuilianoSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.ORCID 0000-0002-1054-2650
Jose I SaldañaSchool of Health, Sport and Bioscience, University of East London, Water Lane, London E15 4LZ, UK.
Yvette van KooykDepartment of Molecular Cell Biology and Immunology, Amsterdam UMC, Location Vrije Universiteit Amsterdam, O12 Building Postbox 7057, 1007 MB Amsterdam, The Netherlands.
Giovanna LombardiMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.
Lesley A SmythMRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London SE1 9RT, UK.

Funding

British Heart Foundation PG/17/53/33079
6 · The paper itself

Abstract

Mature dendritic cells (DCs) are known to activate effector immune responses, whereas steady state immature DCs can induce tolerance. Several studies have targeted immature murine quiescent DCs in vivo with antigen, including donor alloantigens, for the induction of tolerance. Receptors expressed by specific DC subsets have been also targeted with antibodies linked with antigens to induce tolerance; for instance, in vivo targeting of the DCIR2

Indexed as

Dendritic CellsGraft SurvivalIsoantigensN-Acetylneuraminic AcidSkin TransplantationAnimalsFemaleMiceMice, Inbred C57BLSialic Acid Binding Immunoglobulin-like LectinsT-Lymphocytes, RegulatoryIsoantigensN-Acetylneuraminic AcidSialic Acid Binding Immunoglobulin-like Lectinsallorecognitiondendritic cellssiglecstolerance

Identifiers

PMID40649945
PMCPMC12250551

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.